D
Douglas W. Ball
Researcher at Johns Hopkins University School of Medicine
Publications - 50
Citations - 5179
Douglas W. Ball is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Medullary thyroid cancer & Thyroid cancer. The author has an hindex of 28, co-authored 47 publications receiving 4705 citations. Previous affiliations of Douglas W. Ball include University of Pisa.
Papers
More filters
Journal ArticleDOI
Cabozantinib in Progressive Medullary Thyroid Cancer
Rossella Elisei,Martin Schlumberger,Stefan P. Müller,Patrick Schöffski,Marcia S. Brose,Manisha H. Shah,Lisa Licitra,Barbara Jarzab,Viktor Medvedev,Michael C. Kreissl,Bruno Niederle,Ezra E.W. Cohen,Lori J. Wirth,Haythem Ali,Colin Hessel,Yifah Yaron,Douglas W. Ball,Barry D. Nelkin,Steven I. Sherman +18 more
TL;DR: Cabozantinib (140 mg per day) achieved a statistically significant improvement of PFS in patients with progressive metastatic MTC and represents an important new treatment option for patients with this rare disease.
Journal ArticleDOI
Notch mediates TGFα-induced changes in epithelial differentiation during pancreatic tumorigenesis
Yoshiharu Miyamoto,Anirban Maitra,Bidyut Ghosh,Ulrich Zechner,Pedram Argani,Christine A. Iacobuzio-Donahue,Virote Sriuranpong,Tatsuya Iso,Ingrid M. Meszoely,Michael S. Wolfe,Ralph H. Hruban,Douglas W. Ball,Roland M. Schmid,Steven D. Leach +13 more
TL;DR: It is suggested that Notch mediates the tumor-initiating effects of TG alpha by expanding a population of undifferentiated precursor cells.
Journal ArticleDOI
Activity of XL184 (cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer
Razelle Kurzrock,Steven I. Sherman,Douglas W. Ball,Arlene A. Forastiere,Roger B. Cohen,Ranee Mehra,David G. Pfister,Ezra E.W. Cohen,Linda Janisch,Forlisa Nauling,David S. Hong,Chaan S. Ng,Lei Ye,Robert F. Gagel,John W. Frye,Thomas Müller,Mark J. Ratain,Ravi Salgia +17 more
TL;DR: Cabozantinib has an acceptable safety profile and is active in MTC, and may provide clinical benefit by simultaneously targeting multiple pathways of importance in M TC, including MET, VEGFR2, and RET.
Journal Article
Notch Signaling Induces Cell Cycle Arrest in Small Cell Lung Cancer Cells
Virote Sriuranpong,Michael Borges,Rajani Ravi,Dagmar R. Arnold,Barry D. Nelkin,Stephen B. Baylin,Douglas W. Ball +6 more
TL;DR: Notch activation, in the setting of a highly proliferative hASH1-dependent NE neoplasm, can be associated with growth arrest and apparent reduction in neoplastic potential, suggesting that the previously described function of Notch proteins as proto-oncogenes is highly context-dependent.
Journal ArticleDOI
Conservation of the Drosophila lateral inhibition pathway in human lung cancer: A hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression
Herbert Chen,Arunthathi Thiagalingam,Hemi Chopra,Michael Borges,John N. Feder,Barry D. Nelkin,Stephen B. Baylin,Douglas W. Ball +7 more
TL;DR: Evidence is provided that the protein hairy-enhancer-of-split-1 (HES-1) acts in a similar manner as its Drosophila homolog, hairy, to transcriptionally repress achaete-scute expression, indicating a key part of the process that determines neural fate in Dosophila is conserved in human lung cancer cells.