Notch mediates TGFα-induced changes in epithelial differentiation during pancreatic tumorigenesis
Yoshiharu Miyamoto,Anirban Maitra,Bidyut Ghosh,Ulrich Zechner,Pedram Argani,Christine A. Iacobuzio-Donahue,Virote Sriuranpong,Tatsuya Iso,Ingrid M. Meszoely,Michael S. Wolfe,Ralph H. Hruban,Douglas W. Ball,Roland M. Schmid,Steven D. Leach +13 more
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TLDR
It is suggested that Notch mediates the tumor-initiating effects of TG alpha by expanding a population of undifferentiated precursor cells.About:
This article is published in Cancer Cell.The article was published on 2003-06-01 and is currently open access. It has received 659 citations till now. The article focuses on the topics: Notch proteins & Notch signaling pathway.read more
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Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
Sunil R. Hingorani,Emanuel F. Petricoin,Anirban Maitra,Vinodh N. Rajapakse,Catrina King,Michael A. Jacobetz,Sally Ross,Thomas P. Conrads,Timothy D. Veenstra,Ben A. Hitt,Yoshiya Kawaguchi,Donald J. Johann,Lance A. Liotta,Howard C. Crawford,Mary E. Putt,Tyler Jacks,Christopher V.E. Wright,Ralph H. Hruban,Andrew M. Lowy,David A. Tuveson +19 more
TL;DR: It is found that physiological levels of Kras(G12D) induce ductal lesions that recapitulate the full spectrum of human pancreatic intraepithelial neoplasias (PanINs), putative precursors to invasive pancreatic cancer.
Journal ArticleDOI
Genetics and biology of pancreatic ductal adenocarcinoma
Haoqiang Ying,Prasenjit Dey,Wantong Yao,Alec C. Kimmelman,Giulio Draetta,Anirban Maitra,Ronald A. DePinho +6 more
TL;DR: The path to meaningful clinical progress has never been clearer to improve PDAC patient survival and a deeper understanding of cancer cell biology, particularly altered cancer cell metabolism and impaired DNA repair processes, is providing novel therapeutic strategies that show strong preclinical activity.
Journal ArticleDOI
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice.
Carmen Guerra,Alberto J. Schuhmacher,Marta Cañamero,Paul J. Grippo,Lena Verdaguer,Lucía Pérez-Gallego,Pierre Dubus,Eric P. Sandgren,Mariano Barbacid +8 more
TL;DR: It is reported that selective expression of an endogenous K-Ras(G12V) oncogene in embryonic cells of acinar/centroacinar lineage results in pancreatic intraepithelial neoplasias (PanINs) and invasive PDA, suggesting that PDA originates by differentiation of acINs or their precursors into ductal-like cells.
Journal ArticleDOI
Expression profiling identifies microRNA signature in pancreatic cancer
Eun Joo Lee,Yuriy Gusev,Jinmai Jiang,Gerard J. Nuovo,Megan R. Lerner,Megan R. Lerner,Wendy L. Frankel,Daniel L. Morgan,Russell G. Postier,Daniel J. Brackett,Daniel J. Brackett,Thomas D. Schmittgen +11 more
TL;DR: A microRNA expression signature has been identified that is associated with pancreatic cancer and Aberrant microRNAs may offer new clues to pancreatic tumorigenesis and may provide diagnostic biomarkers for pancreatic adenocarcinoma.
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Hedgehog signalling in cancer formation and maintenance.
TL;DR: The Hedgehog signalling pathway is essential for numerous processes during embryonic development, but the overall activity of the pathway is diminished after embryogenesis, recent reports show that the pathway remains active in some adult tissues, including adult stem cells in the brain and skin.
References
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Journal ArticleDOI
Notch Signaling: Cell Fate Control and Signal Integration in Development
TL;DR: Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a fundamental role in metazoan development, providing a general developmental tool to influence organ formation and morphogenesis.
PatentDOI
A simplified system for generating recombinant adenoviruses
TL;DR: In this paper, a recombinant adenoviral plasmid is generated with a minimum of enzymatic manipulations, employing homologous recombination in bacteria rather than in eucaryotic cells.
Journal ArticleDOI
Cancer statistics, 2002.
TL;DR: The American Cancer Society estimated the number of new cancer cases and deaths expected in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival, using National Cancer Institute (NCI) incidence and National Center for Health Statistics (NCHS) mortality data as mentioned in this paper.
Journal ArticleDOI
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
Bart De Strooper,Wim Annaert,Philippe Cupers,Paul Saftig,Katleen Craessaerts,Jeff S. Mumm,Eric H. Schroeter,Vincent Schrijvers,Michael S. Wolfe,William J. Ray,Alison Goate,Raphael Kopan +11 more
TL;DR: It is reported that, in mammalian cells, PS1 deficiency also reduces the proteolytic release of NICD from a truncated Notch construct, thus identifying the specific biochemical step of the Notch signalling pathway that is affected by PS1.
Journal ArticleDOI
Notch signalling controls pancreatic cell differentiation
Åsa Apelqvist,Hao Li,Lukas Sommer,Paul Beatus,David J. Anderson,Tasuku Honjo,Martin Hrabě de Angelis,Urban Lendahl,Helena Edlund +8 more
TL;DR: Evidence is provided that ngn3 acts as pro-endocrine gene and that Notch signalling is critical for the decision between theendocrine and progenitor/exocrine fates in the developing pancreas.
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