Angel Cedazo-Minguez

TL;DR: This poster aims to demonstrate the efforts towards in-situ applicability of EMMARM, which aims to provide real-time information about the physical and cognitive properties of Alzheimer's disease and other dementias.

TL;DR: It is shown that loss of DJ-1 leads to loss of mitochondrial polarization, fragmentation of mitochondria and accumulation of markers of autophagy around mitochondria in human dopaminergic cells, and data suggest thatDJ-1 works in parallel to the PINK1/parkin pathway to maintain mitochondrial function in the presence of an oxidative environment.

TL;DR: The possibility that the flux of 27-OHC from the circulation into the brain represents the missing link between AD and hypercholesterolemia is explored, and the possibility that modification of this flux may be a therapeutic strategy is discussed.

TL;DR: Physical inactivity, dietary fat intake, alcohol drinking and smoking at midlife are associated with the risk of dementia and AD, especially among the apoE ɛ4 carriers, and thus, lifestyle interventions may greatly modify dementia risk particularly among the genetically susceptible individuals.

TL;DR: The current knowledge about oxidative stress in AD pathogeny is reviewed and future paths that are worth to be explored in animal models and clinical studies are suggested in order to get a better approach of oxidative imbalance in this inexorable neurodegenerative disease.