G
Goran Šinko
Researcher at University of Zagreb
Publications - 49
Citations - 1610
Goran Šinko is an academic researcher from University of Zagreb. The author has contributed to research in topics: Butyrylcholinesterase & Oxime. The author has an hindex of 20, co-authored 46 publications receiving 1328 citations.
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Journal ArticleDOI
Molar absorption coefficients for the reduced Ellman reagent: reassessment.
TL;DR: The data show that the absorbance spectra of TNB are shifted to longer wavelengths when temperature increases, while absorbance maxima decrease, and this should be taken into account when the Ellman method is used for determination of enzyme activities, such as in cholinesterase assays.
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Structural aspects of flavonoids as inhibitors of human butyrylcholinesterase
Maja Katalinić,Gordana Rusak,Jelena Domaćinović Barović,Goran Šinko,Dubravko Jelić,Roberto Antolović,Zrinka Kovarik +6 more
TL;DR: Docking study showed that flavonoids bind to the BChE active site by forming multiple hydrogen bonds and pi-pi interactions, and UV-VIS absorption spectra of the flavonoid phosphate buffer solution revealed time dependant changes indicating precipitation of Flavonoids or in the case of myricetin, a change in the chemical structure resulting in a BChChE non-inhibiting specie.
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Limitation of the Ellman method: cholinesterase activity measurement in the presence of oximes.
TL;DR: In this article, the authors measured the oximolysis between oximes (K027 and HI-6) and ATCh in the presence of DTNB at different pH values, taking into account the final concentration of a product that is thiocholine.
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Response of biochemical biomarkers in the aquatic crustacean Daphnia magna exposed to silver nanoparticles
Lea Ulm,Adela Krivohlavek,Darija Jurašin,Marija Ljubojević,Goran Šinko,Tea Crnković,Irena Žuntar,Sandra Šikić,Ivana Vinković Vrček +8 more
TL;DR: The results indicate significant less toxicity of AgNP compared to free Ag+ ions, indicating that these organisms are a vulnerable link in the aquatic food chain with regard to contamination by nanosilver.
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Pseudo-catalytic scavenging: Searching for a suitable reactivator of phosphorylated butyrylcholinesterase
Zrinka Kovarik,Maja Katalinić,Goran Šinko,Jiri Binder,Ondrej Holas,Young-Sik Jung,Lucie Musilova,Daniel Jun,Daniel Jun,Kamil Kuca +9 more
TL;DR: In vitro reactivation of phosphorylated human plasma BChE by bispyridinium oximes varying in the length and type of the linker between rings, and in the position of the oxime group on the ring is tested.