D
Duncan J. Stewart
Researcher at McGill University
Publications - 56
Citations - 3557
Duncan J. Stewart is an academic researcher from McGill University. The author has contributed to research in topics: Endothelin receptor & Coronary artery disease. The author has an hindex of 16, co-authored 56 publications receiving 3476 citations. Previous affiliations of Duncan J. Stewart include St. Michael's Hospital & University of Toronto.
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Journal ArticleDOI
Expression of Endothelin-1 in the Lungs of Patients with Pulmonary Hypertension
Adel Giaid,Masashi Yanagisawa,David Langleben,René P. Michel,Robert D. Levy,Hani Shennib,Sadao Kimura,Tomoh Masaki,William P. Duguid,Duncan J. Stewart +9 more
TL;DR: Preliminary results suggest that pulmonary hypertension is associated with the increased expression of endothelin-1 in vascular endothelial cells, suggesting that the local production of endethelin- 1 may contribute to the vascular abnormalities associated with this disorder.
Journal ArticleDOI
Immunoreactive endothelin in human plasma: marked elevations in patients in cardiogenic shock.
Peter Cernacek,Duncan J. Stewart +1 more
TL;DR: The present results suggest that circulating irET concentration is responsive to altered cardiovascular conditions, and therefore support a potential role for ET as a vasoactive hormone.
Journal ArticleDOI
Increased plasma endothelin-1 in the early hours of acute myocardial infarction.
TL;DR: Plasma levels of endothelin-1 rose sharply after myocardial infarction, and left ventricular ejection fraction did not correlate with the increase in endothelins-1 in group I patients, whereas there was a significant inverse relation between ventricular function and plasma endothelimus in group II.
Journal ArticleDOI
Elevated endothelin-1 in heart failure and loss of normal response to postural change.
TL;DR: Alterations in plasma levels of endothelin in congestive heart failure and in response to postural change were qualitatively and quantitatively similar to the alterations of known mediators of neurohumoral compensation.
Journal ArticleDOI
Short-term Pulmonary Vasodilation With l-Arginine in Pulmonary Hypertension
TL;DR: An exaggerated short-term pulmonary vasodilatory response to L-arginine in patients with pulmonary hypertension suggests a relative impairment in pulmonary vascular endothelial NO production that may contribute to increased pulmonary vascular tone and thus be important in the pathophysiology of pulmonary hypertension.