William P. Duguid

TL;DR: Preliminary results suggest that pulmonary hypertension is associated with the increased expression of endothelin-1 in vascular endothelial cells, suggesting that the local production of endethelin- 1 may contribute to the vascular abnormalities associated with this disorder.

TL;DR: A reproducible method is reported for the long-term culture of pancreatic duct epithelial cells derived from normal and benign adult human pancreata by infection with a retrovirus containing the E6 and E7 genes of the human papilloma virus 16.

TL;DR: Apocalyptic cell death appears soon after islet isolation, and involves primarily the &bgr; cell, the first report of apoptosis of islet cells after human islet isolate.

TL;DR: A new model is described in the Syrian golden hamster for inducing duct epithelial hyperplasia and nesidioblastosis that will be of use in studies of pancreatic carcinogenesis and will enhance knowledge of the interrelationships between etiologic factors, precursor lesions, and pancreatic cancer.

TL;DR: The results suggest that HGF and Met expression may play significant bifunctional roles during human pancreatic ductal carcinogenesis and progression and an upregulation of Met receptor expression and HGF-Met interaction may have an important pathogenetic role during the early stages of neoplastic promotion.