D
Duncan Sproul
Researcher at Edinburgh Cancer Research Centre
Publications - 29
Citations - 3456
Duncan Sproul is an academic researcher from Edinburgh Cancer Research Centre. The author has contributed to research in topics: DNA methylation & Gene. The author has an hindex of 21, co-authored 23 publications receiving 3115 citations. Previous affiliations of Duncan Sproul include University of Nottingham & Western General Hospital.
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Journal ArticleDOI
Recruitment to the nuclear periphery can alter expression of genes in human cells.
Lee E Finlan,Duncan Sproul,Inga Thomson,Shelagh Boyle,Elizabeth Kerr,Paul Perry,Bauke Ylstra,Jonathan R. Chubb,Wendy A. Bickmore +8 more
TL;DR: The data show that the radial position within the nucleus can influence the expression of some, but not all, genes, compatible with the suggestion that re-localisation of genes relative to the peripheral zone of the nucleus could be used by metazoans to modulate theexpression of selected genes during development and differentiation.
Journal ArticleDOI
Ring1B Compacts Chromatin Structure and Represses Gene Expression Independent of Histone Ubiquitination
Ragnhild Eskeland,Martin Leeb,Graeme R. Grimes,Clémence Kress,Shelagh Boyle,Duncan Sproul,Nick Gilbert,Yuhong Fan,Arthur I. Skoultchi,Anton Wutz,Wendy A. Bickmore +10 more
TL;DR: It is suggested that Ring1B-mediated chromatin compaction acts to directly limit transcription in vivo and to restore a compact chromatin state and to repress Hox gene expression is not dependent on its histone ubiquitination activity.
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Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes
Colm E. Nestor,Raffaele Ottaviano,James P. Reddington,Duncan Sproul,Diana Reinhardt,Donncha S. Dunican,Elad Katz,J Michael Dixon,David J. Harrison,Richard R. Meehan +9 more
TL;DR: The tissue specificity of both the global levels and locus-specific distribution of 5hmC in several human tissues and cell lines is investigated, finding that global 5mC content of normal human tissues is highly variable, does not correlate with global 5MC content, and decreases rapidly as cells from normal tissue adapt to cell culture.
Journal ArticleDOI
The role of chromatin structure in regulating the expression of clustered genes.
TL;DR: Much of what the authors know about the chromatin-based mechanisms that regulate gene expression in mammals has come from the study of what are, paradoxically, atypical genes.
Journal ArticleDOI
Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression
Tom Latham,Logan Mackay,Duncan Sproul,Muhammed Karim,Jayne Culley,David J. Harrison,Larry Hayward,Patrick R. R. Langridge-Smith,Nick Gilbert,Bernard Ramsahoye +9 more
TL;DR: The results suggest that lactate may be an important transcriptional regulator, linking the metabolic state of the cell to gene transcription, and the primary effect of HDAC inhibition by endogenous short-chain fatty acids like lactate is to promote gene expression at genes associated with HDAC proteins.