D
Durga P. Neupane
Researcher at Cornell University
Publications - 7
Citations - 58
Durga P. Neupane is an academic researcher from Cornell University. The author has contributed to research in topics: Salmonella typhi & Typhoid fever. The author has an hindex of 3, co-authored 7 publications receiving 21 citations.
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Journal ArticleDOI
Mechanisms of typhoid toxin neutralization by antibodies targeting glycan receptor binding and nuclease subunits.
Changhwan Ahn,Yi-An Yang,Durga P. Neupane,Tri Nguyen,Angelene F. Richards,Ji Hyun Sim,Nicholas J. Mantis,Nicholas J. Mantis,Jeongmin Song +8 more
TL;DR: It is demonstrated that antibiotic-resistant S. Typhi secretes typhoid toxin continuously during infection regardless of antibiotic treatment, as demonstrated by using Typhi during human cell infection and lethal dose typhoid toxins challenge to mice.
Journal ArticleDOI
Enteric Fever Diagnosis: Current Challenges and Future Directions
TL;DR: The pros and cons of currently available diagnostic tests for enteric fever, the advancement of research toward improved diagnostic tests, and the challenges of discovering new ideal biomarkers and tests are discussed.
Journal ArticleDOI
The structural basis of Salmonella A2B5 toxin neutralization by antibodies targeting the glycan-receptor binding subunits.
Tri Nguyen,Angelene F. Richards,Durga P. Neupane,J. Ryan Feathers,Yi-An Yang,Ji Hyun Sim,Haewon Byun,Sohyoung Lee,Changhwan Ahn,Greta Van Slyke,J. Christopher Fromme,Nicholas J. Mantis,Jeongmin Song +12 more
TL;DR: In this paper, the molecular mechanism by which neutralizing antibodies, which have the potential to bind to all glycan-receptor binding sites and thus completely inhibit toxin binding to host cells, are inhibited from exerting this action was presented.
Posted ContentDOI
The molecular basis of extensively drug-resistant Salmonella Typhi isolates from pediatric septicemia patients
Chanmi Kim,Iqra Latif,Durga P. Neupane,Gi Young Lee,Ryan S. Kwon,Alia Batool,Qasim Ahmed,Muhammad Usman Qamar,Jeongmin Song +8 more
TL;DR: In this paper, the authors characterized XDR S. Typhi isolates from a medium size cohort of pediatric typhoid patients to determine their antibiotic-resistance-related gene signatures associated with common treatment options to typhoid fever patients.
Journal ArticleDOI
The molecular basis of extensively drug-resistant Salmonella Typhi isolates from pediatric septicemia patients.
Chanmi Kim,Iqra Latif,Durga P. Neupane,Gi Young Lee,Ryan S. Kwon,Alia Batool,Qasim Ahmed,Muhammad Usman Qamar,Jeongmin Song +8 more
TL;DR: In this article, the authors characterized antibiotic-resistance profiles of XDR S. Typhi isolates from a medium size cohort of pediatric typhoid patients (n = 45, 68.89% male and 31.11% female) and determined antibiotic-related gene signatures associated with common treatment options to typhoid fever patients.