S
Satoshi Kanazawa
Researcher at Nagoya City University
Publications - 39
Citations - 3975
Satoshi Kanazawa is an academic researcher from Nagoya City University. The author has contributed to research in topics: Focal adhesion & Idiopathic pulmonary fibrosis. The author has an hindex of 18, co-authored 34 publications receiving 3819 citations. Previous affiliations of Satoshi Kanazawa include Saitama University & University of California, San Francisco.
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Journal ArticleDOI
Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice
Dusko Ilic,Yasuhide Furuta,Satoshi Kanazawa,Naoki Takeda,Kenji Sobue,Norio Nakatsuji,S Nomura,Jiro Fujimoto,Masato Okada,Tadashi Yamamoto +9 more
TL;DR: Surprisingly, the number of focal adhesions was increased in FAK-deficient cells, suggesting that FAK may be involved in the turnover of focalAdhesion contacts during cell migration.
Journal ArticleDOI
NF-κB Binds P-TEFb to Stimulate Transcriptional Elongation by RNA Polymerase II
Matjaz Barboric,Matjaz Barboric,Robert M. Nissen,Satoshi Kanazawa,Nabila Jabrane-Ferrat,B. Matija Peterlin +5 more
TL;DR: NF-kappaB requires P-teFb to stimulate the elongation of transcription and P-TEFb plays an unexpected role in regulating apoptosis, and it is found that the activation of transcription by RelA also depends on P- TEFb.
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Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection.
TL;DR: CIITA is a novel cellular coactivator that binds to P-TEFb for the expression of its target genes in HIV and the bare lymphocyte syndrome.
Journal Article
Mesodermal defect in late phase of gastrulation by a targeted mutation of focal adhesion kinase, FAK.
TL;DR: The results suggest that FAK mediates fibronectin-integrin interactions uniquely at this stage of development, thereby playing an essential role in development of mesodermal cell lineages.
Journal Article
Wnt Pathway Activation in Mesothelioma Evidence of Dishevelled Overexpression and Transcriptional Activity of β-Catenin
Kazutsugu Uematsu,Satoshi Kanazawa,Liang You,Biao He,Zhidong Xu,Kai Li,B. Matija Peterlin,Frank McCormick,David M. Jablons +8 more
TL;DR: The data suggest that in malignant pleural mesothelioma, Wnt signaling is activated through Dvl overexpression and downstream signaling through beta-catenin and this signaling leads to significant antitumor effects.