E
E. Ron de Kloet
Researcher at Leiden University Medical Center
Publications - 65
Citations - 9480
E. Ron de Kloet is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Glucocorticoid receptor & Glucocorticoid. The author has an hindex of 37, co-authored 63 publications receiving 8812 citations. Previous affiliations of E. Ron de Kloet include Leiden University.
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Stress and the brain: from adaptation to disease
TL;DR: In response to stress, the brain activates several neuropeptide-secreting systems, which eventually leads to the release of adrenal corticosteroid hormones, which subsequently feed back on the brain and bind to two types of nuclear receptor that act as transcriptional regulators as mentioned in this paper.
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Stress and cognition: are corticosteroids good or bad guys?
TL;DR: This paper argues that the paradox of corticosteroid effects on cognition can be explained by appreciating the specific role of both mineralocorticoid and glucocortioid receptors in the various stages of information processing.
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Hippocampal Apoptosis in Major Depression Is a Minor Event and Absent from Subareas at Risk for Glucocorticoid Overexposure
Paul J. Lucassen,Marianne B. Müller,Florian Holsboer,Jan Bauer,Anne Holtrop,Jose Wouda,Witte J.G. Hoogendijk,E. Ron de Kloet,Dick F. Swaab +8 more
TL;DR: The detection of apoptosis in 11 of 15 depressed patients, in three steroid-treated, and in one control patient, demonstrates for the first time that apoptosis is involved in steroid-related changes in the human hippocampus.
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MicroRNA 18 and 124a Down-Regulate the Glucocorticoid Receptor: Implications for Glucocorticoid Responsiveness in the Brain
Erno Vreugdenhil,Carla S Verissimo,Rob Mariman,Jessica T. Kamphorst,Joana S. Barbosa,Thijs Jan Zweers,Danielle L. Champagne,Theo G. Schouten,Onno C. Meijer,E. Ron de Kloet,Carlos P. Fitzsimons +10 more
TL;DR: A potential role for miRs is demonstrated in the regulation of cell type-specific responsiveness to GCs, as may occur during critical periods of neuronal development, which may provide a better understanding of the etiology of stress-related diseases as well as the efficacy of GC therapy.
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Mineralocorticoid and glucocorticoid receptors at the neuronal membrane, regulators of nongenomic corticosteroid signalling.
TL;DR: Nongenomic corticosteroid actions in the brain are required for the coordination of a rapid adaptive response to stress; membrane-associated MRs and GRs play a major role herein.