Vanesa Martín

TL;DR: This report reviews the studies which document the influence of melatonin on the activity and expression of the antioxidative enzymes glutathione peroxidase, superoxide dismutases and catalase both under physiological and under conditions of elevated oxidative stress and analyses the possible mechanisms by which melatonin regulates these enzymes.

TL;DR: The methylation and chromatin status of the miR-124a loci in ALL provided the grounds for new therapeutic strategies in ALL either targeting the epigenetic regulation of microRNAs and/or directly targeting the CDK6-Rb pathway.

TL;DR: Melatonin, at physiological serum concentrations, increases the mRNA of both superoxide dismutases (SODs) and glutathione peroxidase (GPx) in two neuronal cell lines and suggests that the regulation of AOE gene expression is likely to be receptor mediated.

TL;DR: It is found that the antioxidant melatonin prevents cell death as well as the damage induced by chronic administration of MPTP measured as number of nigral cells, tyrosine hydroxylase levels, and several ultra-structural features.

TL;DR: It is found that millimolar concentrations of this indolamine reduced cell growth of C6 glioma cells by 70% after 72 hours of treatment, inhibiting cell progression from G(1) to S phase of the cell cycle.