V
Vincent Ling
Researcher at Genetics Institute, Inc.
Publications - 46
Citations - 8169
Vincent Ling is an academic researcher from Genetics Institute, Inc.. The author has contributed to research in topics: Fusion protein & CD28. The author has an hindex of 22, co-authored 46 publications receiving 7459 citations.
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Journal ArticleDOI
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.
Gordon J. Freeman,Andrew J. Long,Yoshiko Iwai,Karen Bourque,Tatyana Chernova,Hiroyuki Nishimura,Lori Fitz,Nelly Malenkovich,Taku Okazaki,Michael C. Byrne,Heidi F. Horton,Lynette A. Fouser,Laura L. Carter,Vincent Ling,Michael R Bowman,Beatriz M. Carreno,Mary Collins,Clive Wood,Tasuku Honjo +18 more
TL;DR: It is reported here that the ligand of PD-1 (PD-L1), an immunoinhibitory receptor expressed by activated T cells, B cells, and myeloid cells, is a member of the B7 gene family.
Journal ArticleDOI
ICOS is critical for CD40-mediated antibody class switching
Alexander J. McAdam,Rebecca J. Greenwald,Michele A. Levin,Tatyana Chernova,Nelly Malenkovich,Vincent Ling,Gordon J. Freeman,Arlene H. Sharpe +7 more
TL;DR: Mice lacking ICOS exhibit profound deficits in immunoglobulin isotype class switching, accompanied by impaired germinal centre formation, and class switching was restored in ICOS-/- mice by CD40 stimulation, showing that ICOS promotes T-cell/B-cell collaboration through the CD40/CD40L pathway.
Journal ArticleDOI
Mouse Inducible Costimulatory Molecule (ICOS) Expression Is Enhanced by CD28 Costimulation and Regulates Differentiation of CD4+ T Cells
Alexander J. McAdam,Alexander J. McAdam,Tammy T. Chang,Anna E. Lumelsky,Edward A. Greenfield,Vassiliki A. Boussiotis,Jonathan S. Duke-Cohan,Tatyana Chernova,Nelly Malenkovich,Claudia Jabs,Vijay K. Kuchroo,Vincent Ling,Mary Collins,Arlene H. Sharpe,Gordon J. Freeman +14 more
TL;DR: Investigating the role of ICOS in activation of CD4+ T cells and its role in Th responses demonstrated that ICOS stimulation is important in T cell activation and thatICOS may have a particularly important role in development of Th2 cells.
Journal ArticleDOI
The B7 family of immune-regulatory ligands
TL;DR: The B7 family consists of structurally related, cell-surface protein ligands, which bind to the CD28 family of receptors on lymphocytes and regulate immune responses via 'costimulatory' or 'coinhibitory' signals.
Journal ArticleDOI
Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses.
Frann Bennett,Deborah Luxenberg,Vincent Ling,I-Ming Wang,Kim Marquette,David C. Lowe,Nighat Khan,Geertruida M. Veldman,Kenneth Jacobs,Viia Valge-Archer,Mary Collins,Beatriz M. Carreno +11 more
TL;DR: It is suggested that IL-7 and IL-15 restore proliferation under conditions of PD-1 engagement by enhancing high-affinity IL-2R expression and hence,IL-2 responsiveness, and thus, STAT5 has been implicated in the maintenance of IL- 2Rα expression.