H
Harri Lähdesmäki
Researcher at Aalto University
Publications - 192
Citations - 8954
Harri Lähdesmäki is an academic researcher from Aalto University. The author has contributed to research in topics: Cellular differentiation & Gene. The author has an hindex of 44, co-authored 173 publications receiving 7098 citations. Previous affiliations of Harri Lähdesmäki include Tampere University of Technology & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans
Tommi Vatanen,Tommi Vatanen,Aleksandar Kostic,Aleksandar Kostic,Eva d'Hennezel,Heli Siljander,Eric A. Franzosa,Eric A. Franzosa,Moran Yassour,Raivo Kolde,Hera Vlamakis,Timothy D. Arthur,Anu Maaria Hämäläinen,Aleksandr Peet,Vallo Tillmann,Raivo Uibo,Sergei Mokurov,Natalya Dorshakova,Jorma Ilonen,Jorma Ilonen,Suvi M. Virtanen,Suvi M. Virtanen,Susanne J. Szabo,Jeffrey A. Porter,Harri Lähdesmäki,Curtis Huttenhower,Curtis Huttenhower,Dirk Gevers,Thomas W. Cullen,Mikael Knip,Ramnik J. Xavier +30 more
TL;DR: It is shown that Bacteroides LPS is structurally distinct from E. coli LPS and inhibits innate immune signaling and endotoxin tolerance, and that early colonization by immunologically silencing microbiota may preclude aspects of immune education.
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The Dynamics of the Human Infant Gut Microbiome in Development and in Progression toward Type 1 Diabetes
Aleksandar Kostic,Aleksandar Kostic,Dirk Gevers,Heli Siljander,Tommi Vatanen,Tommi Vatanen,Tuulia Hyötyläinen,Tuulia Hyötyläinen,Anu-Maaria Hämäläinen,Aleksandr Peet,Vallo Tillmann,Päivi Pöhö,Päivi Pöhö,Ismo Mattila,Ismo Mattila,Harri Lähdesmäki,Eric A. Franzosa,Outi Vaarala,Marcus C. de Goffau,Hermie J. M. Harmsen,Jorma Ilonen,Jorma Ilonen,Suvi M. Virtanen,Suvi M. Virtanen,Clary B. Clish,Matej Orešič,Matej Orešič,Curtis Huttenhower,Curtis Huttenhower,Mikael Knip,Ramnik J. Xavier +30 more
TL;DR: Trends in the development of the human infant gut microbiome along with specific alterations that precede T1D onset and distinguish T2D progressors from nonprogressors are identified.
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The human gut microbiome in early-onset type 1 diabetes from the TEDDY study
Tommi Vatanen,Eric A. Franzosa,Eric A. Franzosa,Randall Schwager,Surya Tripathi,Timothy D. Arthur,Kendra Vehik,Åke Lernmark,William Hagopian,Marian Rewers,Jin-Xiong She,Jorma Toppari,Jorma Toppari,Anette-G. Ziegler,Beena Akolkar,Jeffrey P. Krischer,Christopher J. Stewart,Christopher J. Stewart,Nadim J. Ajami,Joseph F. Petrosino,Dirk Gevers,Dirk Gevers,Harri Lähdesmäki,Hera Vlamakis,Curtis Huttenhower,Curtis Huttenhower,Ramnik J. Xavier,Ramnik J. Xavier,Ramnik J. Xavier +28 more
TL;DR: An analysis of more than 10,000 metagenomes from the TEDDY study provides a detailed functional profile of the gut microbiome in relation to islet autoimmunity, and supports the protective effects of short-chain fatty acids in early-onset type 1 diabetes.
Journal ArticleDOI
The Transcription Factor NFAT Promotes Exhaustion of Activated CD8+ T Cells
Gustavo J. Martinez,Renata M. Pereira,Tarmo Äijö,Tarmo Äijö,Edward Y. Kim,Francesco Marangoni,Matthew E. Pipkin,Matthew E. Pipkin,Susan Togher,Vigo Heissmeyer,Yi Chen Zhang,Shane Crotty,Edward D. Lamperti,K. Mark Ansel,Thorsten R. Mempel,Harri Lähdesmäki,Patrick G. Hogan,Anjana Rao +17 more
TL;DR: It is demonstrated that the transcription factor NFAT controls the program of T cell exhaustion and promotes T cell anergy and exhaustion by binding at sites that do not require cooperation with AP-1.
Journal ArticleDOI
Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX
Myunggon Ko,Jungeun An,Hozefa S. Bandukwala,Lukas Chavez,Tarmo Äijö,Tarmo Äijö,William A. Pastor,William A. Pastor,Matthew Segal,Huiming Li,Huiming Li,Kian Peng Koh,Kian Peng Koh,Harri Lähdesmäki,Patrick G. Hogan,L. Aravind,Anjana Rao,Anjana Rao +17 more
TL;DR: It is shown that IDAX, a reported inhibitor of Wnt signalling that has been implicated in malignant renal cell carcinoma and colonic villous adenoma, regulates TET2 protein expression, and that the expression and activity of TET3 is also regulated through its CXXC domain.