K
Kian Peng Koh
Researcher at Katholieke Universiteit Leuven
Publications - 32
Citations - 8483
Kian Peng Koh is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 12, co-authored 27 publications receiving 7499 citations. Previous affiliations of Kian Peng Koh include University of California, Los Angeles & Harvard University.
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Journal ArticleDOI
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Mamta Tahiliani,Kian Peng Koh,Yinghua Shen,William A. Pastor,Hozefa S. Bandukwala,Yevgeny Brudno,Suneet Agarwal,Lakshminarayan M. Iyer,David R. Liu,L. Aravind,Anjana Rao +10 more
TL;DR: It is shown here that TET1, a fusion partner of the MLL gene in acute myeloid leukemia, is a 2-oxoglutarate (2OG)- and Fe(II)-dependent enzyme that catalyzes conversion of 5mC to 5-hydroxymethylcytosine (hmC) in cultured cells and in vitro.
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Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
Myunggon Ko,Yun Huang,Yun Huang,Anna M. Jankowska,Utz Johann Pape,Utz Johann Pape,Mamta Tahiliani,Hozefa S. Bandukwala,Jungeun An,Jungeun An,Edward D. Lamperti,Kian Peng Koh,Rebecca D. Ganetzky,X. Shirley Liu,L. Aravind,Suneet Agarwal,Jaroslaw P. Maciejewski,Anjana Rao,Anjana Rao +18 more
TL;DR: The results demonstrate that Tet2 is important for normal myelopoiesis, and suggest that disruption of TET2 enzymatic activity favours myeloid tumorigenesis, which may prove valuable as a diagnostic and prognostic tool to tailor therapies and assess responses to anticancer drugs.
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Tet1 and Tet2 Regulate 5-Hydroxymethylcytosine Production and Cell Lineage Specification in Mouse Embryonic Stem Cells
Kian Peng Koh,Akiko Yabuuchi,Sridhar Rao,Yun Huang,Kerrianne Cunniff,Julie Nardone,Asta Laiho,Mamta Tahiliani,Cesar Sommer,Gustavo Mostoslavsky,Riitta Lahesmaa,Riitta Lahesmaa,Stuart H. Orkin,Stuart H. Orkin,Stuart H. Orkin,Scott J. Rodig,George Q. Daley,Anjana Rao +17 more
TL;DR: 5hmC is an epigenetic modification associated with the pluripotent state, and Tet1 functions to regulate the lineage differentiation potential of ESCs.
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Tumour hypoxia causes DNA hypermethylation by reducing TET activity
Bernard Thienpont,Jessica Steinbacher,Hui Zhao,Flora D’Anna,Anna Kuchnio,Athanasios Ploumakis,Bart Ghesquière,Laurien Van Dyck,Bram Boeckx,Luc Schoonjans,Els Hermans,Frédéric Amant,Vessela N. Kristensen,Kian Peng Koh,Massimiliano Mazzone,Mathew L. Coleman,Thomas Carell,Peter Carmeliet,Diether Lambrechts +18 more
TL;DR: Tumour hypoxia acts as a novel regulator of DNA methylation in tumour suppressor genes by reducing the activity of oxygen-dependent ten-eleven translocation enzymes in human and mouse cells.
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Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX
Myunggon Ko,Jungeun An,Hozefa S. Bandukwala,Lukas Chavez,Tarmo Äijö,Tarmo Äijö,William A. Pastor,William A. Pastor,Matthew Segal,Huiming Li,Huiming Li,Kian Peng Koh,Kian Peng Koh,Harri Lähdesmäki,Patrick G. Hogan,L. Aravind,Anjana Rao,Anjana Rao +17 more
TL;DR: It is shown that IDAX, a reported inhibitor of Wnt signalling that has been implicated in malignant renal cell carcinoma and colonic villous adenoma, regulates TET2 protein expression, and that the expression and activity of TET3 is also regulated through its CXXC domain.