H
Hozefa S. Bandukwala
Researcher at La Jolla Institute for Allergy and Immunology
Publications - 28
Citations - 8596
Hozefa S. Bandukwala is an academic researcher from La Jolla Institute for Allergy and Immunology. The author has contributed to research in topics: DNA methylation & T cell. The author has an hindex of 19, co-authored 28 publications receiving 7711 citations. Previous affiliations of Hozefa S. Bandukwala include Harvard University & University of Chicago.
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Journal ArticleDOI
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Mamta Tahiliani,Kian Peng Koh,Yinghua Shen,William A. Pastor,Hozefa S. Bandukwala,Yevgeny Brudno,Suneet Agarwal,Lakshminarayan M. Iyer,David R. Liu,L. Aravind,Anjana Rao +10 more
TL;DR: It is shown here that TET1, a fusion partner of the MLL gene in acute myeloid leukemia, is a 2-oxoglutarate (2OG)- and Fe(II)-dependent enzyme that catalyzes conversion of 5mC to 5-hydroxymethylcytosine (hmC) in cultured cells and in vitro.
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Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
Myunggon Ko,Yun Huang,Yun Huang,Anna M. Jankowska,Utz Johann Pape,Utz Johann Pape,Mamta Tahiliani,Hozefa S. Bandukwala,Jungeun An,Jungeun An,Edward D. Lamperti,Kian Peng Koh,Rebecca D. Ganetzky,X. Shirley Liu,L. Aravind,Suneet Agarwal,Jaroslaw P. Maciejewski,Anjana Rao,Anjana Rao +18 more
TL;DR: The results demonstrate that Tet2 is important for normal myelopoiesis, and suggest that disruption of TET2 enzymatic activity favours myeloid tumorigenesis, which may prove valuable as a diagnostic and prognostic tool to tailor therapies and assess responses to anticancer drugs.
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Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice
Myunggon Ko,Hozefa S. Bandukwala,Jungeun An,Edward D. Lamperti,Elizabeth C. Thompson,Ryan Hastie,Angeliki Tsangaratou,Klaus Rajewsky,Sergei B. Koralov,Anjana Rao +9 more
TL;DR: It is shown that Tet2 is a critical regulator of self-renewal and differentiation of hematopoietic stem cells (HSCs) and has a critical role in regulating the expansion and function of HSCs, presumably by controlling 5hmC levels at genes important for the self-Renewal, proliferation, and differentiation.
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Transcription factor IRF4 drives dendritic cells to promote Th2 differentiation.
Jesse W. Williams,Melissa Y. Tjota,Bryan S. Clay,Bryan Vander Lugt,Hozefa S. Bandukwala,Cara L. Hrusch,Donna C. Decker,Kelly M. Blaine,Bethany Fixsen,Harinder Singh,Roger Sciammas,Anne I. Sperling +11 more
TL;DR: A regulatory module in DCs is revealed by which IRF4 modulates IL-10 and IL-33 cytokine production to specifically promote Th2 differentiation and inflammation.
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Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX
Myunggon Ko,Jungeun An,Hozefa S. Bandukwala,Lukas Chavez,Tarmo Äijö,Tarmo Äijö,William A. Pastor,William A. Pastor,Matthew Segal,Huiming Li,Huiming Li,Kian Peng Koh,Kian Peng Koh,Harri Lähdesmäki,Patrick G. Hogan,L. Aravind,Anjana Rao,Anjana Rao +17 more
TL;DR: It is shown that IDAX, a reported inhibitor of Wnt signalling that has been implicated in malignant renal cell carcinoma and colonic villous adenoma, regulates TET2 protein expression, and that the expression and activity of TET3 is also regulated through its CXXC domain.