E
Edward J. Pearce
Researcher at Max Planck Society
Publications - 237
Citations - 34759
Edward J. Pearce is an academic researcher from Max Planck Society. The author has contributed to research in topics: Schistosoma mansoni & Immune system. The author has an hindex of 81, co-authored 218 publications receiving 30184 citations. Previous affiliations of Edward J. Pearce include National Institutes of Health & Ithaca College.
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Long-term suppression of cathepsin B levels by RNA interference retards schistosome growth.
TL;DR: New light is shed on the role of SmCB1 and the report provides a template for using RNAi to examine gene function in the mammal-parasitic stages of schistosomes during early development in vitro and in vivo.
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Immunology of Parasitic Helminth Infections
TL;DR: Parasitic helminths, or worms, comprise a diverse group of metazoan organisms that infect billions of people and their domesticated animals worldwide.
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Cutting Edge: IPSE/alpha-1, a Glycoprotein from Schistosoma mansoni Eggs, Induces IgE-Dependent, Antigen-Independent IL-4 Production by Murine Basophils In Vivo
Gabriele Schramm,Katja Mohrs,Maren Wodrich,Michael J. Doenhoff,Edward J. Pearce,Helmut L. Haas,Markus Mohrs +6 more
TL;DR: It is demonstrated that the S. mansoni egg Ag (SmEA) induces IgE-dependent IL-4 production by basophils derived from Heligmosomoides polygyrus-infected or OVA/alum-immunized mice in the absence of pathogen-specific IgE, mediated by the secretory glycoprotein IPSE/alpha-1.
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Cutting Edge: Dendritic Cells Copulsed with Microbial and Helminth Antigens Undergo Modified Maturation, Segregate the Antigens to Distinct Intracellular Compartments, and Concurrently Induce Microbe-Specific Th1 and Helminth-Specific Th2 Responses
TL;DR: Data suggest that segregation of SEA and Pa into distinct compartments, coupled with SEA-induced modifications of the DC maturation pathway, are significant components of the ability of DC to interpret signals inherent toSEA and Pa and induce appropriately polarized Th responses.
Journal Article
CD4+ Th2 response induced by Schistosoma mansoni eggs develops rapidly, through an early, transient, Th0-like stage.
TL;DR: Results show that schistosome eggs are autonomous inducers of vigorous Th2-like effector responses, and depletion studies indicate that CD4 cells are the major population responsible for Ag-mediated proliferation and cytokine production.