Edward J. Pearce

TL;DR: The results suggest a previously unknown and unreported role of hepatic macrophages in the modulation of whole body lipid and glucose metabolism during infection and provide a template for examining the role of immunomodulation on the long-term metabolism of the host.

TL;DR: Recent advances in the development of tools for studying gene function in schistosomes are reviewed and how these new tools may be exploited to investigate issues of key importance in the interaction of schistOSomes with the host immune system are discussed.

TL;DR: This article found that IL-3-induced Janus kinase 2-dependent expression of SLC7A5 and SLC3A2 was required for mammalian target of rapamycin complex 1 (mTORC1) nutrient sensor activation in response to toll-like receptor agonists.

TL;DR: The hypothesis that the intradermal vaccine acts through induction of T‐cell‐mediated immune resistance mechanisms is strengthened, as vaccinated P and BALB/c mice showed specific defects in cell‐mediated immunity to schistosome antigens, including decreased production of macrophage‐activating lymphokines and an inability to produce activated macrophages at the site of antigen challenge.

TL;DR: The guinea-pig has been reassessed as a potential laboratory host for Schistosoma mansoni and the fact that schistosome eggs are deposited in the lungs of these animals indicates that portal systemic anastomosis is a feature of the model.