E
Edward J. Pearce
Researcher at Max Planck Society
Publications - 237
Citations - 34759
Edward J. Pearce is an academic researcher from Max Planck Society. The author has contributed to research in topics: Schistosoma mansoni & Immune system. The author has an hindex of 81, co-authored 218 publications receiving 30184 citations. Previous affiliations of Edward J. Pearce include National Institutes of Health & Ithaca College.
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Th2 cell hyporesponsiveness during chronic murine schistosomiasis is cell intrinsic and linked to GRAIL expression
TL;DR: Data indicate that the decline in Th2 cell responsiveness during chronic schistosomiasis is the net result of the upregulation of GRAIL expression in response to repeated Ag stimulation in vitro or in vivo.
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GAM: a web-service for integrated transcriptional and metabolic network analysis.
Alexey Sergushichev,Alexander A. Loboda,Abhishek K. Jha,Emma E. Vincent,Edward M. Driggers,Russell G. Jones,Edward J. Pearce,Maxim N. Artyomov +7 more
TL;DR: GAM (‘genes and metabolites’): a web-service for integrated network analysis of transcriptional and steady-state metabolomic data focused on identification of the most changing metabolic subnetworks between two conditions of interest is presented.
Journal Article
Nitric Oxide and the Th2 Response Combine to Prevent Severe Hepatic Damage During Schistosoma mansoni Infection
TL;DR: The underlying importance of NO is illustrated by the finding that aminoguanidine treatment leads to more severe liver disease and reduced time to death in infected IL-4-/- mice.
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piggyBac transposon mediated transgenesis of the human blood fluke, Schistosoma mansoni
Maria E. Morales,Victoria H. Mann,Kristine J. Kines,Geoffrey N. Gobert,Malcolm J. Fraser,Bernd H. Kalinna,Jason Correnti,Edward J. Pearce,Paul J. Brindley +8 more
TL;DR: In this paper, a piggyBac donor plasmid modified to encode firefly luciferase under control of schistosome gene promoters was introduced along with 7-methylguanosine capped RNAs encoding piggy-Bac transposase into cultured schistusomula by square wave electroporation.
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An essential role of Th1 responses and interferon gamma in infection-mediated suppression of neoplastic growth
Erinn B. Rankin,Duonan Yu,Jiu Jiang,Hao Shen,Edward J. Pearce,Michael H. Goldschmidt,David E Levy,Tatyana V. Golovkina,Christopher A. Hunter,Andrei Thomas-Tikhonenko +9 more
TL;DR: Interestingly, the enhancement was also apparent in uninfected animals suggesting that IFNg and its anti-angiogenic effects underlie both infection-dependent and -independent tumor surveillance.