E
Edward M. Callaway
Researcher at Salk Institute for Biological Studies
Publications - 185
Citations - 24182
Edward M. Callaway is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Visual cortex & Visual system. The author has an hindex of 75, co-authored 175 publications receiving 20891 citations. Previous affiliations of Edward M. Callaway include University of California, San Diego & Rockefeller University.
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Journal ArticleDOI
Monosynaptic Restriction of Transsynaptic Tracing from Single, Genetically Targeted Neurons
Ian R. Wickersham,David C. Lyon,Richard J. O. Barnard,Takuma Mori,Stefan Finke,Karl-Klaus Conzelmann,John A. T. Young,Edward M. Callaway +7 more
TL;DR: A transsynaptic tracer that crosses only one synaptic step is presented, unambiguously identifying cells directly presynaptic to the starting population, and should enable a far more detailed understanding of neural connectivity than has previously been possible.
Journal ArticleDOI
In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration
Keiichiro Suzuki,Yuji Tsunekawa,Reyna Hernández-Benítez,Reyna Hernández-Benítez,Jun Wu,Jun Wu,Jie Zhu,Jie Zhu,Euiseok J. Kim,Fumiyuki Hatanaka,Mako Yamamoto,Toshikazu Araoka,Toshikazu Araoka,Zhe Li,Masakazu Kurita,Tomoaki Hishida,Mo Li,Emi Aizawa,Shicheng Guo,Song Chen,April Goebl,Rupa Devi Soligalla,Jing Qu,Tingshuai Jiang,Xin Fu,Xin Fu,Maryam Jafari,Concepcion Rodriguez Esteban,W. Travis Berggren,Jeronimo Lajara,Estrella Núñez-Delicado,Pedro Guillen,Josep M. Campistol,Fumio Matsuzaki,Guang-Hui Liu,Pierre J. Magistretti,Kun Zhang,Edward M. Callaway,Kang Zhang,Juan Carlos Izpisua Belmonte +39 more
TL;DR: The HITI method presented here establishes new avenues for basic research and targeted gene therapies and demonstrates the efficacy of HITI in improving visual function using a rat model of the retinal degeneration condition retinitis pigmentosa.
Journal ArticleDOI
Genetic dissection of neural circuits.
TL;DR: Progress in the genetic analysis of neural circuits is reviewed and directions for future research and development are discussed, including genetic approaches to nongenetic systems such as primates.
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Genetic Dissection of an Amygdala Microcircuit That Gates Conditioned Fear
Wulf Haubensak,Prabhat S. Kunwar,Haijiang Cai,Stephane Ciocchi,Nicholas R. Wall,Ravikumar Ponnusamy,Jonathan Biag,Hong-Wei Dong,Karl Deisseroth,Edward M. Callaway,Michael S. Fanselow,Andreas Lüthi,David J. Anderson +12 more
TL;DR: Molecular genetic approaches are used to map the functional connectivity of a subpopulation of GABA-containing neurons, located in the lateral subdivision of the central amygdala (CEl), which express protein kinase C-δ (PKC- δ) and define an inhibitory microcircuit in CEl that gates CEm output to control the level of conditioned freezing.
Journal ArticleDOI
Parallel processing strategies of the primate visual system
TL;DR: Multiple strategies including retinal tiling, hierarchical and parallel processing and modularity, defined spatially and by cell type-specific connectivity, are used by the visual system to recover the intricate detail of the authors' visual surroundings.