E
Edward W. Kraegen
Researcher at Garvan Institute of Medical Research
Publications - 196
Citations - 22873
Edward W. Kraegen is an academic researcher from Garvan Institute of Medical Research. The author has contributed to research in topics: Insulin & Insulin resistance. The author has an hindex of 75, co-authored 196 publications receiving 21967 citations. Previous affiliations of Edward W. Kraegen include Chinese Academy of Sciences & University of Sydney.
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Journal ArticleDOI
Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle *
Chunli Yu,Yan Chen,Gary W. Cline,Dongyan Zhang,Haihong Zong,Yanlin Wang,Raynald Bergeron,Jason K. Kim,Samuel W. Cushman,Gregory J. Cooney,Bronwyn Atcheson,Morris F. White,Edward W. Kraegen,Gerald I. Shulman +13 more
TL;DR: The hypothesis that an increase in plasma fatty acid concentration results in a increase in intracellular fatty acyl-CoA and DAG concentrations, which results in activation of PKC-θ leading to increased IRS-1 Ser307 phosphorylation is supported.
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Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.
Margaret E. Griffin,Melissa Marcucci,Gary W. Cline,K. I. M. S. Bell,Nicole Barucci,Dennis Lee,Laurie J. Goodyear,Edward W. Kraegen,Morris F. White,Gerald I. Shulman +9 more
TL;DR: It is concluded that acute elevations of plasma FFA levels for 5 h induce skeletal muscle insulin resistance in vivo via a reduction in insulin-stimulated muscle glycogen synthesis and glucose oxidation that can be attributed to reduced glucose transport activity.
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Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid.
Leonard H Storlien,Arthur B. Jenkins,Donald J. Chisholm,Wendy S. Pascoe,Sue Khouri,Edward W. Kraegen +5 more
TL;DR: It is concluded that the particular fatty acids and the lipid environment in which they are presented in high-fat diets determine insulin sensitivity in rats and impaired insulin action in skeletal muscle relates to triglyceride accumulation, suggesting intracellular glucose–fatty acid cycle involvement.
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Berberine, a Natural Plant Product, Activates AMP-Activated Protein Kinase With Beneficial Metabolic Effects in Diabetic and Insulin-Resistant States
Yun Sok Lee,Woo S Kim,Kang H Kim,Myung J Yoon,Hye Jin Cho,Yun Shen,Ji-Ming Ye,Chul H Lee,Oh Won Keun,Chul Tae Kim,Cordula Hohnen-Behrens,Alison Gosby,Edward W. Kraegen,David E. James,JaeBum Kim +14 more
TL;DR: It is suggested that berberine displays beneficial effects in the treatment of diabetes and obesity at least in part via stimulation of AMPK activity.
Journal ArticleDOI
Fish oil prevents insulin resistance induced by high-fat feeding in rats
Leonard H Storlien,Edward W. Kraegen,Donald J. Chisholm,Glenn L. Ford,D. G. Bruce,Wendy S. Pascoe +5 more
TL;DR: In rats fed high-fat diets, replacement of only 6 percent of the linoleic omega-6 fatty acids from safflower oil with long-chain polyunsaturated omega-3 fatty acids with fish oil prevented the development of insulin resistance.