Ji-Ming Ye

TL;DR: It is suggested that berberine displays beneficial effects in the treatment of diabetes and obesity at least in part via stimulation of AMPK activity.

TL;DR: In this article, the authors investigated the mechanism of activation of AMP-activated protein kinase (AMPK) by BBR and explored whether derivatization of BBR could improve its in vivo efficacy.

TL;DR: Findings indicate that cucurbitane triterpenoids, the characteristic constituents of M. charantia, may provide leads as a class of therapeutics for diabetes and obesity.

TL;DR: Even though WY14643 and pioglitazone, representing PPAR-alpha and PPar-gamma activation, respectively, may alter muscle lipid supply by different mechanisms, both significantly improve muscle insulin action in the high fat-fed rat model of insulin resistance, and this effect is proportional to the degree to which they reduce muscle lipid accumulation.

TL;DR: A single dose of AICAR leads to an apparent enhancement in whole-body, muscle, and liver insulin action in HF rats that extends beyond the expected time of AM PK activation, and the results suggest that pharmacological activation of AMPK may have potential in treating insulin-resistant states and type 2 diabetes.