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Yun Sok Lee
Researcher at University of California, San Diego
Publications - 47
Citations - 6092
Yun Sok Lee is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Insulin resistance & Adipose tissue. The author has an hindex of 31, co-authored 45 publications receiving 5008 citations. Previous affiliations of Yun Sok Lee include KAIST & Seoul National University.
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Journal ArticleDOI
Berberine, a Natural Plant Product, Activates AMP-Activated Protein Kinase With Beneficial Metabolic Effects in Diabetic and Insulin-Resistant States
Yun Sok Lee,Woo S Kim,Kang H Kim,Myung J Yoon,Hye Jin Cho,Yun Shen,Ji-Ming Ye,Chul H Lee,Oh Won Keun,Chul Tae Kim,Cordula Hohnen-Behrens,Alison Gosby,Edward W. Kraegen,David E. James,JaeBum Kim +14 more
TL;DR: It is suggested that berberine displays beneficial effects in the treatment of diabetes and obesity at least in part via stimulation of AMPK activity.
Journal ArticleDOI
Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet–Induced Insulin Resistance
Yun Sok Lee,Pingping Li,Jin Young Huh,In Jae Hwang,Min Lu,Jong In Kim,Mira Ham,Saswata Talukdar,Ai Chen,Wendell J. Lu,Guatam K. Bandyopadhyay,Reto A. Schwendener,Jerrold M. Olefsky,Jae Bum Kim +13 more
TL;DR: Data suggest that the initial stage of HFD-induced insulin resistance is independent of inflammation, whereas the more chronic state of insulin resistance in established obesity is largely mediated by macrophage-induced proinflammatory actions.
Journal ArticleDOI
miR-27a is a negative regulator of adipocyte differentiation via suppressing PPARγ expression
Sang Yun Kim,A Young Kim,Hyun-Woo Lee,You Hwa Son,Gha Young Lee,Joo-Won Lee,Yun Sok Lee,Jae Bum Kim +7 more
TL;DR: It is revealed that miR-27a is involved in adipocyte differentiation by binding to the PPARgamma 3'-UTR whose sequence motifs are highly conserved in mammals and which might be associated with adipose tissue dysregulation in obesity.
Journal ArticleDOI
Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity
Yun Sok Lee,Jung Whan Kim,Olivia Osborne,Da Young Oh,Roman Sasik,Simon Schenk,Ai Chen,Heekyung Chung,Anne N. Murphy,Steven M. Watkins,Oswald Quehenberger,Randall S. Johnson,Randall S. Johnson,Randall S. Johnson,Jerrold M. Olefsky +14 more
TL;DR: Early in the course of high-fat diet (HFD) feeding and obesity, adipocyte respiration becomes uncoupled, leading to increased oxygen consumption and a state of relative adipocyte hypoxia, which triggers HIF-1α induction, setting off the chronic adipose tissue inflammatory response characteristic of obesity.
Journal ArticleDOI
An Integrated View of Immunometabolism
TL;DR: The major features of the current understanding with respect to chronic obesity-related inflammation in metabolic tissues are reviewed and how these inflammatory changes affect insulin sensitivity, insulin secretion, food intake, and glucose homeostasis are reviewed.