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Eeva-Liisa Eskelinen
Researcher at University of Turku
Publications - 136
Citations - 32990
Eeva-Liisa Eskelinen is an academic researcher from University of Turku. The author has contributed to research in topics: Autophagy & Endosome. The author has an hindex of 60, co-authored 124 publications receiving 28293 citations. Previous affiliations of Eeva-Liisa Eskelinen include Dalhousie University & University of Kiel.
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Journal ArticleDOI
Basal Autophagy Is Altered in Lagotto Romagnolo Dogs with an ATG4D Mutation.
Pernilla Syrjä,Tahira Anwar,Tarja S. Jokinen,Kaisa Kyöstilä,Karin Hultin Jäderlund,Francesca Cozzi,Cecilia Rohdin,Kerstin Hahn,Peter Wohlsein,Wolfgang Baumgärtner,Diana Henke,Anna Oevermann,Antti Sukura,Tosso Leeb,Hannes Lohi,Eeva-Liisa Eskelinen +15 more
TL;DR: The results show that basal but not induced autophagy is altered in affected fibroblasts, and the ultrastructure of affected cells is compatible with altered autophagic and endo-lysosomal vesicular traffic.
Journal ArticleDOI
Vacuole membrane protein 1 marks endoplasmic reticulum subdomains enriched in phospholipid synthesizing enzymes and is required for phosphoinositide distribution.
Luis-Carlos Tábara,Juan-Jesus Vicente,Joanna M. Biazik,Eeva-Liisa Eskelinen,Olivier Vincent,Ricardo Escalante +5 more
TL;DR: The role of VMP1 in lipid trafficking is expanded to include endoplasmic reticulum domains enriched in lipid synthesizing enzymes, which might be necessary for efficient distribution of PtdIns4P and perhaps other lipid species.
Journal ArticleDOI
GIMAP6 is required for T cell maintenance and efficient autophagy in mice.
John C. Pascall,Louise M. C. Webb,Eeva-Liisa Eskelinen,Silvia Innocentin,Noudjoud Attaf-Bouabdallah,Geoffrey W. Butcher +5 more
TL;DR: A requirement for GIMAP6 in the maintenance of a normal peripheral adaptive immune system and a significant role for the protein in normal autophagic processes are indicated.
Journal ArticleDOI
Calpain mobilizes Atg9/Bif-1 vesicles from Golgi stacks upon autophagy induction by thapsigargin
Elena Marcassa,Marzia Raimondi,Tahira Anwar,Eeva-Liisa Eskelinen,Michael P. Myers,Gianluca Triolo,Claudio Schneider,Francesca Demarchi +7 more
TL;DR: Data indicate that calpain allows dynamic flux of Atg9/Bif-1 vesicles from the Golgi toward the budding autophagosome, which triggers calpain-dependent B if-1 activation and induction of autophagy maturation by promoting ATG9/ Bif- 1 vesicle trafficking and fusion with LC3 bodies.
Book ChapterDOI
Correlative Light and Electron Microscopy of Autophagosomes.
Sigurdur Runar Gudmundsson,Jenny Kahlhofer,Nastassia Baylac,Katri Kallio,Eeva-Liisa Eskelinen +4 more
TL;DR: Live-cell imaging has been widely used to study autophagosome biogenesis and maturation and when combined with correlative electron microscopy, this approach can be extended to reveal ultrastructural details in three dimensions.