Eeva-Liisa Eskelinen

TL;DR: The molecular chaperone Hsp70, proteasomes and autophagy have an important regulatory role in the protein turnover of human RPE cells and may thus open new avenues for understanding degenerative processes in retinal cells.

TL;DR: The current data imply that PPT has a role outside the lysosomes in the brain and may be associated with synaptic functioning, which opens a new route to study the neuropathological events associated with INCL.

TL;DR: Data indicate that vti1b is specifically required for the stability of a single SNARE partner, and suggests that other SNAREs can compensate for the reduction in syntaxin 8 and for the loss of vti2b in most mice even though vti 1b shows only 30% amino acid identity with its closest relative.

TL;DR: This work has used serial block face scanning electron microscopy and electron tomography to image phagophore biogenesis in 3 dimensions and to determine the relationship between the phagophile and surrounding organelles at high resolution, and identified MCSs between thephagophores and membranes from putative ER exit sites, late endosomes or lysosomes, the Golgi complex and mitochondria.

TL;DR: It is proposed that the redox-sensitivity of p62 may have evolved in vertebrates as a mechanism that allows activation of autophagy in response to oxidative stress to maintain cellular homoeostasis and increase cell survival.