E
Eileen Ingham
Researcher at University of Leeds
Publications - 333
Citations - 20247
Eileen Ingham is an academic researcher from University of Leeds. The author has contributed to research in topics: Decellularization & Tissue engineering. The author has an hindex of 74, co-authored 331 publications receiving 19073 citations. Previous affiliations of Eileen Ingham include Leeds General Infirmary & University of Bath.
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Journal ArticleDOI
Biological reactions to wear debris in total joint replacement.
Eileen Ingham,John Fisher +1 more
TL;DR: It is concluded that the pre-clinical testing of any new materials for joint replacement must include an analysis of the wear particle characteristics and their biological reactivity in addition to the usual assessment of wear.
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The role of macrophages in osteolysis of total joint replacement.
Eileen Ingham,John Fisher +1 more
TL;DR: Evidence is provided that bone marrow-derived macrophages may play a dual role in osteolysis associated with total joint replacement, as the major cell in host defence responding to UHMWPE particles via the production of cytokines and secondly as precursors for the osteoclasts responsible for the ensuing bone resorption.
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Release of the angiogenic cytokine vascular endothelial growth factor (VEGF) from platelets: significance for VEGF measurements and cancer biology.
Rosamonde E. Banks,M A Forbes,Sally E. Kinsey,Anthea J. Stanley,Eileen Ingham,C E Walters,Peter Selby +6 more
TL;DR: The presence of VEGF within platelets has implications for processes involving platelet and endothelial cell interactions, e.g. wound healing, and in tumour metastasis, when platelets adhering to circulating tumour cells may release V EGF at points of adhesion to endothelium, leading to hyperpermeability and extravasation of cells.
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Polyethylene particles of a ‘critical size’ are necessary for the induction of cytokines by macrophages in vitro
TL;DR: Particulate wear debris from total hip prosthetic components can stimulate macrophages to produce mediators of osteolysis which may cause aseptic implant loosening and particles in the phagocytosable size range of 0.3-10 microm appear to be the most biologically active.
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The effect of nano- and micron-sized particles of cobalt–chromium alloy on human fibroblasts in vitro
I. Papageorgiou,Chris Brown,R Schins,Sarabjot Singh,Roger Newson,Sean A. Davis,John Fisher,Eileen Ingham,C. P. Case +8 more
TL;DR: The mechanism of cell damage appears to be different after exposure to nanoparticles and microparticles, and the concept of nanotoxicology is an important consideration in the design of future surgical devices.