Journal ArticleDOI
The effect of nano- and micron-sized particles of cobalt–chromium alloy on human fibroblasts in vitro
I. Papageorgiou,Chris Brown,R Schins,Sarabjot Singh,Roger Newson,Sean A. Davis,John Fisher,Eileen Ingham,C. P. Case +8 more
TLDR
The mechanism of cell damage appears to be different after exposure to nanoparticles and microparticles, and the concept of nanotoxicology is an important consideration in the design of future surgical devices.About:
This article is published in Biomaterials.The article was published on 2007-07-01. It has received 366 citations till now. The article focuses on the topics: Nanotoxicology & Nanoparticle.read more
Citations
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Journal ArticleDOI
Mechanisms of nanoparticle-induced oxidative stress and toxicity.
TL;DR: Through physicochemical characterization and understanding of the multiple signaling cascades activated by NP-induced ROS, a systemic toxicity screen with oxidative stress as a predictive model for NP- induced injury can be developed.
Journal ArticleDOI
NanoGenotoxicology: The DNA damaging potential of engineered nanomaterials
Neenu Singh,Bella B. Manshian,Gareth J.S. Jenkins,Sioned M. Griffiths,Paul M. Williams,Thierry G.G. Maffeis,Chris J. Wright,Shareen H. Doak +7 more
TL;DR: Many of the engineered nanomaterials assessed were found to cause genotoxic responses, such as chromosomal fragmentation, DNA strand breakages, point mutations, oxidative DNA adducts and alterations in gene expression profiles.
Journal ArticleDOI
Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials: the role of particle size, shape and composition.
TL;DR: The comparative analysis demonstrated that particle composition probably played a primary role in the cytotoxic effects of different nanoparticles, however, the potential genotoxicity might be mostly attributed to particle shape.
Journal ArticleDOI
DNA damaging potential of zinc oxide nanoparticles in human epidermal cells.
TL;DR: The data demonstrates that ZnO NPs even at low concentrations possess a genotoxic potential in human epidermal cells which may be mediated through lipid peroxidation and oxidative stress, Hence, caution should be taken in their use in dermatological preparations as well as while handling.
Journal ArticleDOI
Mechanisms of genotoxicity. A review of in vitro and in vivo studies with engineered nanoparticles.
TL;DR: The need for appropriate methodologies to be used for investigation of genotoxic effects of NPs, in vitro and in vivo is suggested and advantages and potential problems with different methods are described.
References
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Journal ArticleDOI
A simple technique for quantitation of low levels of DNA damage in individual cells
TL;DR: Human lymphocytes were exposed to X-irradiation or treated with H2O2 and the extent of DNA migration was measured using a single-cell microgel electrophoresis technique under alkaline conditions and this technique appears to be sensitive and useful for detecting damage and repair in single cells.
Journal ArticleDOI
Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles
TL;DR: Results of older bio-kinetic studies with NSPs and newer epidemiologic and toxicologic studies with airborne ultrafine particles can be viewed as the basis for the expanding field of nanotoxicology, which can be defined as safety evaluation of engineered nanostructures and nanodevices.
Journal ArticleDOI
Ultrafine Particles Cross Cellular Membranes by Nonphagocytic Mechanisms in Lungs and in Cultured Cells
Marianne Geiser,Barbara Rothen-Rutishauser,Nadine Kapp,Samuel Schürch,Samuel Schürch,Wolfgang G. Kreyling,Holger Schulz,Manuela Semmler,Vinzenz Im Hof,Joachim Heyder,Peter Gehr +10 more
TL;DR: Inhaled ultrafine titanium dioxide particles were found on the luminal side of airways and alveoli, in all major lung tissue compartments and cells, and within capillaries, while particle uptake in vitro did not occur by any of the expected endocytic processes, but rather by diffusion or adhesive interactions.
Journal ArticleDOI
The potential risks of nanomaterials: a review carried out for ECETOC
Paul J. A. Borm,David Robbins,Stephan Haubold,Thomas A. J. Kuhlbusch,Heinz Fissan,Ken Donaldson,Roel P. F. Schins,Vicki Stone,Wolfgang G. Kreyling,Jürgen Lademann,Jean Krutmann,David B. Warheit,Eva Oberdörster +12 more
TL;DR: This review shows that only few specific nanoparticles have been investigated in a limited number of test systems and extrapolation of this data to other materials is not possible, and limited ecotoxicological data for nanomaterials precludes a systematic assessment of the impact of Nanoparticles on ecosystems.
Book
Generalized Linear Models and Extensions
James W. Hardin,Joseph Hilbe +1 more
TL;DR: In this paper, the authors present a detailed overview of generalized linear models for estimating variance matrices in a generalised linear model (GLM) using an offset in a GLM.