E
Eitan Shaulian
Researcher at Hebrew University of Jerusalem
Publications - 23
Citations - 10415
Eitan Shaulian is an academic researcher from Hebrew University of Jerusalem. The author has contributed to research in topics: Transcription factor & JUNB. The author has an hindex of 19, co-authored 22 publications receiving 9072 citations. Previous affiliations of Eitan Shaulian include Weizmann Institute of Science & University of California, San Diego.
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Journal ArticleDOI
Differential regulation of FBXW7 isoforms by various stress stimuli.
TL;DR: Differential regulation of the 3 Fbw7 isoforms is suggested, found to be the most potently induced p53 target gene in HCT-116 cells.
Journal ArticleDOI
Transcriptional repression of c-Jun's E3 ubiquitin ligases contributes to c-Jun induction by UV.
TL;DR: It is demonstrated that the expression of all three E3 ubiquitin ligases of c-Jun is down-regulated by UV, and abrogation of Fbw7 UV-responsiveness abolishes c- Jun induction byUV, and knockdown of F bw7 results in elevated basal expression ofc-Jun but reduced UV-dependent induction thus, proving the essential role of this repression in c-jun induction by UV.
Journal ArticleDOI
Induction of transcriptionally active Jun proteins regulates drug-induced senescence.
TL;DR: HU induces the expression of two AP-1 proteins, c-Jun and JunB, which exert antagonistic effects on the cell cycle, and it is suggested that in contrast to c- Jun, JunB drives cells to enter HU-dependent senescence.
Journal ArticleDOI
Depletion of the AP-1 repressor JDP2 induces cell death similar to apoptosis.
Mads Lerdrup,Christian Holmberg,Nikolaj Dietrich,Eitan Shaulian,T Herdegen,Marja Jäättelä,Tuula Kallunki +6 more
TL;DR: The studies suggest that JDP2 functions as a general survival protein, not only following UV-irradiation, as reported earlier, but also under normal culture conditions, and support that J DP2 is a cellular survival protein whose presence is necessary for normal cellular function.
Journal ArticleDOI
Jun proteins inhibit autophagy and induce cell death.
Orli Yogev,Eitan Shaulian +1 more
TL;DR: Deregulation of JunB expression when autophagy is specifically required, tilts the fate of starved cells to apoptosis.