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Eladio Abreu
Researcher at University of Georgia
Publications - 5
Citations - 918
Eladio Abreu is an academic researcher from University of Georgia. The author has contributed to research in topics: Cajal body & Telomerase reverse transcriptase. The author has an hindex of 5, co-authored 5 publications receiving 862 citations.
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Journal ArticleDOI
A Human Telomerase Holoenzyme Protein Required for Cajal Body Localization and Telomere Synthesis
Andrew S. Venteicher,Eladio Abreu,Zhaojing Meng,Kelly E. McCann,Rebecca M. Terns,Timothy D. Veenstra,Michael P. Terns,Steven E. Artandi +7 more
TL;DR: Depletion of TCAB1 by using RNA interference prevents TERC from associating with Cajal bodies, disrupts telomerase-telomere association, and abrogates telomere synthesis by telomersase.
Journal ArticleDOI
TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo.
Eladio Abreu,Elena Aritonovska,Patrick Reichenbach,Gaël Cristofari,Brad Culp,Rebecca M. Terns,Joachim Lingner,Michael P. Terns +7 more
TL;DR: The findings indicate that TIN2-anchored TPP1 plays a major role in the recruitment of telomerase to telomeres in human cells and that recruitment does not depend on POT1 or interaction of the shelterin complex with the single-stranded region of the telomere.
Journal ArticleDOI
Processive and Distributive Extension of Human Telomeres by Telomerase under Homeostatic and Nonequilibrium Conditions
Yong Zhao,Eladio Abreu,Jinyong Kim,Guido Stadler,Ugur Eskiocak,Michael P. Terns,Rebecca M. Terns,Jerry W. Shay,Woodring E. Wright +8 more
TL;DR: Findings reveal two major distinct extension modes adopted by telomerase in vivo, including Overexpressed telomersase is also less processive than the endogenously expressed telomeres and Cajal bodies may affect its processivity.
Journal ArticleDOI
Telomerase Reverse Transcriptase Is Required for the Localization of Telomerase RNA to Cajal Bodies and Telomeres in Human Cancer Cells
Rebecca L. Tomlinson,Eladio Abreu,Tania D. Ziegler,Hinh Ly,Christopher M. Counter,Rebecca M. Terns,Michael P. Terns +6 more
TL;DR: It is shown that RNA interference-mediated depletion of hTERT in cancer cells leads to loss of hTR from both Cajal bodies and telomeres without affecting hTR levels.
Book ChapterDOI
Visualization of Human Telomerase Localization by Fluorescence Microscopy Techniques
TL;DR: Fluorescence microscopy approaches are described to visualize the subcellular localization of the essential RNA component of telomerase (hTR) relative to Cajal bodies and telomeres in cultured human cells.