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Patrick Reichenbach
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 32
Citations - 3615
Patrick Reichenbach is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Telomerase & Telomerase reverse transcriptase. The author has an hindex of 18, co-authored 27 publications receiving 3373 citations. Previous affiliations of Patrick Reichenbach include Swiss Institute of Bioinformatics & ISREC.
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Journal ArticleDOI
Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends.
TL;DR: It is demonstrated that mammalian telomeres are transcribed into telomeric repeat–containing RNA (TERRA), and SMG factors represent a molecular link between TERRA regulation and the maintenance of telomere integrity.
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DNA binding specificity of different STAT proteins: Comparison of in vitro specificity with natural target sites
Georg B. Ehret,Patrick Reichenbach,Ulrike Schindler,Curt M. Horvath,Stefan Fritz,Markus Nabholz,Philipp Bucher +6 more
TL;DR: Detailed analysis indicated that STAT5A specificity is more similar to that of STAT6 than that ofSTAT1, as expected from the evolutionary relationships.
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The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase
TL;DR: The data identify TERRA as a telomerase ligand and natural direct inhibitor of human telomere substrate, which acts as a potent competitive inhibitor for telomeric DNA in addition to exerting an uncompetitive mode of inhibition.
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Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action
Anne De Cian,Gaël Cristofari,Patrick Reichenbach,Elsa De Lemos,David Monchaud,Marie-Paule Teulade-Fichou,Kazuo Shin-ya,Laurent Lacroix,Joachim Lingner,Jean-Louis Mergny +9 more
TL;DR: The demonstration that these molecules are actually more effective inhibitors of telomeric DNA amplification than extension by telomerase contributes to the already growing suspicion that quadruplex ligands are not simple telomersase inhibitors but, rather, constitute a different class of biologically active molecules.
Journal ArticleDOI
TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo.
Eladio Abreu,Elena Aritonovska,Patrick Reichenbach,Gaël Cristofari,Brad Culp,Rebecca M. Terns,Joachim Lingner,Michael P. Terns +7 more
TL;DR: The findings indicate that TIN2-anchored TPP1 plays a major role in the recruitment of telomerase to telomeres in human cells and that recruitment does not depend on POT1 or interaction of the shelterin complex with the single-stranded region of the telomere.