F
Frank Grosveld
Researcher at Erasmus University Rotterdam
Publications - 446
Citations - 49448
Frank Grosveld is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Gene & Regulation of gene expression. The author has an hindex of 118, co-authored 436 publications receiving 46598 citations. Previous affiliations of Frank Grosveld include National Institute for Medical Research & Memorial Sloan Kettering Cancer Center.
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Position-independent, high-level expression of the human β-globin gene in transgenic mice
TL;DR: The results indicate that the DNA regions flanking the human beta-globin locus contain dominant regulatory sequences that specify position-independent expression and normally activate the complete human multigene beta- globin loci.
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Looping and interaction between hypersensitive sites in the active β-globin locus
TL;DR: It is proposed that clustering of regulatory elements is key to creating and maintaining active chromatin domains and regulating transcription.
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A human monoclonal antibody blocking SARS-CoV-2 infection.
Chunyan Wang,Wentao Li,Dubravka Drabek,Nisreen M.A. Okba,Rien van Haperen,Albert D.M.E. Osterhaus,Frank J. M. van Kuppeveld,Bart L. Haagmans,Frank Grosveld,Berend Jan Bosch +9 more
TL;DR: A human monoclonal antibody is reported capable of neutralizing both authentic SARS-CoV and SARS -CoV-2 by targeting a common epitope on these viruses.
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Atherosclerotic Lesion Size and Vulnerability Are Determined by Patterns of Fluid Shear Stress
Caroline Cheng,Dennie Tempel,Rien van Haperen,Arjen van der Baan,Frank Grosveld,Mat J.A.P. Daemen,Rob Krams,Rini de Crom +7 more
TL;DR: A perivascular shear stress modifier is developed that induces regions of lowered, increased, and lowered/oscillatory (ie, with vortices) shear stresses in mouse carotid arteries and studied plaque formation and composition, finding lowered shear stressed lesions induce larger lesions with a vulnerable plaque phenotype.
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Development of hematopoietic stem cell activity in the mouse embryo
TL;DR: The long-term, complete, and functional hematopoietic repopulation of primary and serial recipients with AGM-derived cells is reported and potent hematopolietic stem cell activity in the AGM region is observed before the appearance of yolk sac and liver stemcell activity.