Eleanor J. Tyler

TL;DR: This work develops CellAge, a manually curated database of 279 human genes driving cellular senescence, and performs various integrative analyses that reveal new insights and gene regulators of cellularsenescence.

TL;DR: It is shown how major, IIS-promoted senescent pathologies in C. elegans can originate not from damage accumulation but from direct effects of futile, continued action of a wild-type biological program (vitellogenesis), which defines a disease syndrome leading to multimorbidity and contributing to late-life mortality.

TL;DR: This work created CellAge, a manually curated database of 279 human genes associated with cellular senescence, and performed various integrative and functional analyses that observed that genes promoting cellsenescence tend to be overexpressed with age in human tissues and are also significantly overrepresented in anti-longevity and tumour-suppressor gene databases.

TL;DR: In this article, a tetra-culture model of primary human mesothelial cells, fibroblasts, adipocytes, and high grade serous ovarian cancer (HGSOC) cell lines was developed.

TL;DR: In this article , the Rho effector protein kinase N2 (PKN2) is shown to be critical for pancreatic stellate cells (PSCs) differentiation into myofibroblast-like cancer-associated fibroblasts (CAFs).