E
Elena E. Pohl
Researcher at University of Veterinary Medicine Vienna
Publications - 93
Citations - 4138
Elena E. Pohl is an academic researcher from University of Veterinary Medicine Vienna. The author has contributed to research in topics: Lipid bilayer & Chemistry. The author has an hindex of 30, co-authored 78 publications receiving 3626 citations. Previous affiliations of Elena E. Pohl include Humboldt University of Berlin & Charité.
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A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment.
Agnieszka Rybak,Heiko Fuchs,Lena Smirnova,Christine Brandt,Elena E. Pohl,Robert Nitsch,F. Gregory Wulczyn +6 more
TL;DR: It is demonstrated that the pluripotency factor Lin-28 binds the pre-let-7 RNA and inhibits processing by the Dicer ribonuclease in ES and EC cells, suggesting that let-7, mir-125 and lin-28 participate in an autoregulatory circuit that controls miRNA processing during NS-cell commitment.
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Metabolic Regulation by the Mitochondrial Phosphatase PTPMT1 Is Required for Hematopoietic Stem Cell Differentiation
Wen Mei Yu,Xia Liu,Jinhua Shen,Olga Jovanovic,Elena E. Pohl,Stanton L. Gerson,Toren Finkel,Hal E. Broxmeyer,Cheng-Kui Qu +8 more
TL;DR: A crucial role is established in the metabolic regulation of HSC function of PTPMT1, a PTEN-like mitochondrial phosphatase, in the regulation and coordination of mitochondrial metabolism with hematopoietic stem cell (HSC) self-renewal and differentiation.
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FGF23 regulates renal sodium handling and blood pressure
Olena Andrukhova,Svetlana Slavic,Alina Smorodchenko,Ute Zeitz,Victoria Shalhoub,Beate Lanske,Elena E. Pohl,Reinhold G. Erben +7 more
TL;DR: It is shown that FGF23 directly regulates the membrane abundance of the Na+:Cl− co‐transporter NCC in distal renal tubules by a signaling mechanism involving the FGF receptor/αKlotho complex, extracellular signal‐regulated kinase 1/2 (ERK1/2), serum/glucocorticoid‐regulatedkinase 1 (SGK1), and with‐no lysine kinase‐4 (WNK4
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Neuronal damage in autoimmune neuroinflammation mediated by the death ligand TRAIL
Orhan Aktas,Alina Smorodchenko,Stefan Brocke,Carmen Infante-Duarte,Ulf Schulze Topphoff,Johannes Vogt,Timour Prozorovski,Susanne Meier,Venera Osmanova,Elena E. Pohl,Ingo Bechmann,Robert Nitsch,Frauke Zipp +12 more
TL;DR: It is found that neurons were susceptible to TRAIL-mediated injury induced by encephalitogenic T cells, and in addition to its known immunoregulatory effects, the death ligand TRAIL contributes to neural damage in the inflamed brain.
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FGF23 promotes renal calcium reabsorption through the TRPV5 channel
Olena Andrukhova,Alina Smorodchenko,Monika Egerbacher,Carmen Streicher,Ute Zeitz,Regina Goetz,Victoria Shalhoub,Moosa Mohammadi,Elena E. Pohl,Beate Lanske,Reinhold G. Erben +10 more
TL;DR: FGF23, not αKlotho, is identified, as a calcium‐conserving hormone in the kidney, and apical membrane abundance of TRPV5 in renal distal tubules and thus renal calcium reabsorption are regulated by FGF23.