E
Elena F. Boer
Researcher at University of Utah
Publications - 17
Citations - 756
Elena F. Boer is an academic researcher from University of Utah. The author has contributed to research in topics: Domestic pigeon & Craniofacial. The author has an hindex of 9, co-authored 16 publications receiving 655 citations. Previous affiliations of Elena F. Boer include National Institutes of Health & Huntsman Cancer Institute.
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Journal ArticleDOI
Inhibition of Interferon-Stimulated JAK-STAT Signaling by a Tick-Borne Flavivirus and Identification of NS5 as an Interferon Antagonist
Sonja M. Best,Keely L. Morris,Jeffrey G. Shannon,Shelly J. Robertson,Dana N. Mitzel,Gregory S. Park,Elena F. Boer,James B. Wolfinbarger,Marshall E. Bloom +8 more
TL;DR: Examination of interactions between NS5 and cellular proteins revealed that NS5 associated with IFN-α/β and -γ receptor complexes, which indicates that this protein may have a significant role in viral pathogenesis.
Journal ArticleDOI
The NS5 Protein of the Virulent West Nile Virus NY99 Strain Is a Potent Antagonist of Type I Interferon-Mediated JAK-STAT Signaling
Maudry Laurent-Rolle,Elena F. Boer,Kirk J. Lubick,James B. Wolfinbarger,Aaron B. Carmody,Barry Rockx,Wen Jun Liu,Joseph Ashour,W. Lesley Shupert,Michael R. Holbrook,Michael R. Holbrook,Alan D.T. Barrett,Peter W. Mason,Peter W. Mason,Marshall E. Bloom,Adolfo García-Sastre,Alexander A. Khromykh,Sonja M. Best +17 more
TL;DR: It is reported that NS5 from the virulent NY99 strain of WNV prevented pY-STAT1 accumulation, suppressedIFN-dependent gene expression, and rescued the growth of a highly IFN-sensitive virus (Newcastle disease virus) in the presence of IFN, suggesting that this protein can function as an efficient IFN antagonist.
Journal ArticleDOI
Flavivirus Antagonism of Type I Interferon Signaling Reveals Prolidase as a Regulator of IFNAR1 Surface Expression.
Kirk J. Lubick,Shelly J. Robertson,Kristin L. McNally,Brett A. Freedman,Angela L. Rasmussen,R. Travis Taylor,Avram D. Walts,Seitaro Tsuruda,Mizuki Sakai,Mariko Ishizuka,Elena F. Boer,Erin C. Foster,Abhilash I. Chiramel,Conrad B. Addison,Richard Green,Daniel L. Kastner,Michael G. Katze,Steven M. Holland,Antonella Forlino,Alexandra F. Freeman,Manfred Boehm,Kentaro Yoshii,Sonja M. Best +22 more
TL;DR: It is reported that encephalitic flaviviruses, including tick-borne encephalitis virus and West Nile virus, antagonize IFN-I signaling by inhibiting IFNAR1 surface expression, a cellular dipeptidase implicated in primary immune deficiencies in humans.
Journal ArticleDOI
Fascin1-Dependent Filopodia are Required for Directional Migration of a Subset of Neural Crest Cells
TL;DR: It is shown that fscn1a-dependent filopodia are required in a subset of NC cells to promote cell migration and NC derivative formation, and that perdurance of long-lived maternal proteins can mask essential zygotic gene functions during NC development.
Journal ArticleDOI
MEK Inhibitors Reverse Growth of Embryonal Brain Tumors Derived from Oligoneural Precursor Cells
Katarzyna Modzelewska,Elena F. Boer,Timothy L. Mosbruger,Daniel Picard,Daniela Anderson,Rodney R. Miles,Mitchell Kroll,William Oslund,Theodore J. Pysher,Joshua D. Schiffman,Randy L. Jensen,Cicely A. Jette,Annie Huang,Rodney A. Stewart +13 more
TL;DR: It is shown that a subset of CNS-PNETs co-express oligoneural precursor cell (OPC) markers OLIG2 and SOX10 with coincident activation of the RAS/MAPK (mitogen-activated protein kinase) pathway, which represents a promising rationally designed therapy for children afflicted with olig oneural/NB-FOXR2 CNS- PNETs.