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Eleni Maria Varypataki
Researcher at University of Zurich
Publications - 15
Citations - 629
Eleni Maria Varypataki is an academic researcher from University of Zurich. The author has contributed to research in topics: CD8 & Cytotoxic T cell. The author has an hindex of 9, co-authored 12 publications receiving 470 citations. Previous affiliations of Eleni Maria Varypataki include Leiden University.
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Journal ArticleDOI
Poly-(lactic-co-glycolic-acid)-based particulate vaccines: Particle uptake by dendritic cells is a key parameter for immune activation
Ana Luisa Silva,Rodney A. Rosalia,Eleni Maria Varypataki,S. Sibuea,Ferry Ossendorp,Wim Jiskoot +5 more
TL;DR: It is postulate that particle internalization is of crucial importance and therefore particulate vaccines should be formulated in the nano- but not micro-size range to achieve efficient uptake, significant MHC class I cross-presentation and effective T and B cell responses.
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Synthetic long peptide-based vaccine formulations for induction of cell mediated immunity: A comparative study of cationic liposomes and PLGA nanoparticles
Eleni Maria Varypataki,Ana Luisa Silva,Christophe Barnier-Quer,Nicolas Collin,Ferry Ossendorp,Wim Jiskoot +5 more
TL;DR: Findings make these two particulate, biodegradable delivery systems promising candidates as delivery platforms for SLP-based immunotherapy of cancer.
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Macrophages inhibit human osteosarcoma cell growth after activation with the bacterial cell wall derivative liposomal muramyl tripeptide in combination with interferon-γ
Jens H.W. Pahl,Kitty M. C. Kwappenberg,Eleni Maria Varypataki,Susy J Santos,Marieke L. Kuijjer,Susan Mohamed,Juul T. Wijnen,Maarten J. D. van Tol,Anne-Marie Cleton-Jansen,R. Maarten Egeler,Wim Jiskoot,Arjan C. Lankester,Marco W. Schilham +12 more
TL;DR: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells.
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Cationic Liposomes Loaded with a Synthetic Long Peptide and Poly(I:C): a Defined Adjuvanted Vaccine for Induction of Antigen-Specific T Cell Cytotoxicity
TL;DR: Cationic liposomes loaded with SLP and poly(I:C) have potential as a powerful therapeutic cancer vaccine formulation and showed an at least 25 fold increase over the T cell frequency induced by the poly( I:C)-adjuvanted soluble SLP.
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Novel Hollow Microneedle Technology for Depth-Controlled Microinjection-Mediated Dermal Vaccination: A Study with Polio Vaccine in Rats
Koen van der Maaden,Sebastiaan Johannes Trietsch,Heleen Kraan,Eleni Maria Varypataki,Stefan Romeijn,Raphaël Zwier,Heiko J. van der Linden,Gideon F.A. Kersten,Thomas Hankemeier,Wim Jiskoot,Joke A. Bouwstra +10 more
TL;DR: A hollow microneedle technology for dermal vaccination that enables fundamental research on factors, such as insertion depth and volume, and insertion angle, on the immune response is successfully developed.