E
Eliana Saxon
Researcher at University of California, Berkeley
Publications - 7
Citations - 4175
Eliana Saxon is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Azide & Glycosylation. The author has an hindex of 7, co-authored 7 publications receiving 3911 citations. Previous affiliations of Eliana Saxon include University of California.
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Journal ArticleDOI
Cell Surface Engineering by a Modified Staudinger Reaction
Eliana Saxon,Carolyn R. Bertozzi +1 more
TL;DR: A chemical transformation that permits the selective formation of covalent adducts among richly functionalized biopolymers within a cellular context is presented and should permit its execution within a cell's interior, offering new possibilities for probing intracellular interactions.
Journal ArticleDOI
Incorporation of azides into recombinant proteins for chemoselective modification by the Staudinger ligation
TL;DR: It is shown that proteins containing azidohomoalanine can be selectively modified in the presence of other cellular proteins by means of Staudinger ligation with triarylphosphine reagents and incorporation of azide-functionalized amino acids into proteins in vivo provides opportunities for protein modification under native conditions and selective labeling of proteins in the intracellular environment.
Journal ArticleDOI
A “Traceless” Staudinger Ligation for the Chemoselective Synthesis of Amide Bonds
TL;DR: A novel modification of the Staudinger ligation that generates an amide bond from an azide and a specifically functionalized phosphine should find general utility in synthetic and biological chemistry.
Journal ArticleDOI
Investigating cellular metabolism of synthetic azidosugars with the Staudinger ligation.
TL;DR: This study investigates the conversion of a panel of azide-functionalized mannosamine and glucosamine derivatives into cell-surface sialosides and demonstrates that the cell- surface Staudinger ligation is compatible with hydrazone formation from metabolically introduced ketones.
Journal ArticleDOI
Chemical and Biological Strategies for Engineering Cell Surface Glycosylation
Eliana Saxon,Carolyn R. Bertozzi +1 more
TL;DR: This review presents an overview of techniques for examining and manipulating cell surface oligosaccharides through genetic, enzymatic, and chemical strategies.