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Elie Fadel
Researcher at Université Paris-Saclay
Publications - 86
Citations - 3442
Elie Fadel is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: Pulmonary hypertension & Lung. The author has an hindex of 27, co-authored 86 publications receiving 2477 citations. Previous affiliations of Elie Fadel include French Institute of Health and Medical Research & University of Paris-Sud.
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Journal ArticleDOI
Pulmonary veno-occlusive disease
David Montani,Edmund M.T. Lau,Peter Dorfmüller,Barbara Girerd,Xavier Jaïs,Laurent Savale,Frédéric Perros,Esther J. Nossent,Gilles Garcia,Florence Parent,Elie Fadel,Florent Soubrier,Olivier Sitbon,Gérald Simonneau,Marc Humbert +14 more
TL;DR: No evidence-based medical therapy exists for PVOD at present and lung transplantation remains the preferred definitive therapy for eligible patients, and advances such as discovery of the genetic basis of PVOD will pave way for future translational research.
Journal ArticleDOI
EIF2AK4 mutations cause pulmonary veno-occlusive disease, a recessive form of pulmonary hypertension
Mélanie Eyries,David Montani,Barbara Girerd,Claire Perret,Anne Leroy,Christine Lonjou,Nadjim Chelghoum,Florence Coulet,Damien Bonnet,Peter Dorfmüller,Elie Fadel,Olivier Sitbon,Gérald Simonneau,David-Alexandre Trégouët,Marc Humbert,Florent Soubrier +15 more
TL;DR: Findings point to EIF2AK4 as the major gene that is linked to PVOD development and contribute toward an understanding of the complex genetic architecture of pulmonary hypertension.
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ERS statement on chronic thromboembolic pulmonary hypertension
Marion Delcroix,Adam Torbicki,Deepa Gopalan,Olivier Sitbon,Frederikus A. Klok,Irene Lang,David J. Jenkins,Nick H. Kim,Marc Humbert,Xavier Jaïs,Anton Vonk Noordegraaf,Joanna Pepke-Zaba,Philippe Brenot,Peter Dorfmüller,Peter Dorfmüller,Elie Fadel,Hossein Ardeschir Ghofrani,Hossein Ardeschir Ghofrani,Marius M. Hoeper,Pavel Jansa,Michael M. Madani,Hiromi Matsubara,Takeshi Ogo,Ekkehard Grünig,Andrea Maria D'Armini,Nazzareno Galiè,Bernhard C. Meyer,Patrick Corkery,Gergely Meszaros,Eckhard Mayer,Gérald Simonneau +30 more
TL;DR: A review of the literature and current practice concerning diagnosis and management of chronic thromboembolic pulmonary hypertension (CTEPH) is presented in this article, which is a rare complication of acute pulmonary embolism, either symptomatic or not.
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Microvascular disease in chronic thromboembolic pulmonary hypertension: a role for pulmonary veins and systemic vasculature.
Peter Dorfmüller,Sven Günther,Maria-Rosa Ghigna,Vincent Thomas de Montpréville,David Boulate,Jean-François Paul,Xavier Jaïs,Benoit Decante,Gérald Simonneau,Philippe Dartevelle,Marc Humbert,Elie Fadel,Olaf Mercier +12 more
TL;DR: Microvascular disease is partly due to post-capillary remodelling in human and experimental CTEPH and appears to be related to bronchial-to-pulmonary venous shunting, and further studies are needed to clinically assess the functional importance of this finding.
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Increased Pericyte Coverage Mediated by Endothelial-Derived Fibroblast Growth Factor-2 and Interleukin-6 Is a Source of Smooth Muscle–Like Cells in Pulmonary Hypertension
Nicolas Ricard,Ly Tu,Morane Le Hiress,Alice Huertas,Carole Phan,Raphaël Thuillet,Caroline Sattler,Elie Fadel,Andrei Seferian,David Montani,Peter Dorfmüller,Marc Humbert,Christophe Guignabert +12 more
TL;DR: In this article, the authors hypothesized that pulmonary endothelial dysfunction, characterized by abnormal fibroblast growth factor-2 and interleukin-6 signaling, leads to abnormal microvascular pericyte coverage causing pulmonary arterial medial thickening.