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Elisabeth Dernbach
Researcher at Goethe University Frankfurt
Publications - 14
Citations - 3418
Elisabeth Dernbach is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Endothelial stem cell & Progenitor cell. The author has an hindex of 14, co-authored 14 publications receiving 3331 citations.
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Journal ArticleDOI
Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells
Carmen Urbich,Alexandra Aicher,Christopher Heeschen,Elisabeth Dernbach,Wolf K. Hofmann,Andreas M. Zeiher,Stefanie Dimmeler +6 more
TL;DR: EPC exhibit a high expression of angiogenic growth factors, which enhanced migration of mature endothelial cells and tissue resident cardiac progenitor cells, and the enhanced expression of cytokines may be a supportive mechanism to improve blood vessel formation and cardiac regeneration after cell therapy.
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Relevance of Monocytic Features for Neovascularization Capacity of Circulating Endothelial Progenitor Cells
Carmen Urbich,Christopher Heeschen,Alexandra Aicher,Elisabeth Dernbach,Andreas M. Zeiher,Stefanie Dimmeler +5 more
TL;DR: It is demonstrated that EPCs can be generated from nonmonocytic CD14− peripheral blood mononuclear cells and exhibit a unique functional activity to improve neovascularization after hind-limb ischemia.
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Phosphorylation of the endothelial nitric oxide synthase at ser-1177 is required for VEGF-induced endothelial cell migration
TL;DR: It is indicated that eNOS activation via phosphorylation of Ser‐1177 by Akt is necessary and sufficient for VEGF‐mediated EC migration.
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Antioxidative stress–associated genes in circulating progenitor cells: evidence for enhanced resistance against oxidative stress
Elisabeth Dernbach,Carmen Urbich,Ralf P. Brandes,Wolf K. Hofmann,Andreas M. Zeiher,Stefanie Dimmeler +5 more
TL;DR: EPCs reveal a higher expression of antioxidative enzymes and are exquisitely equipped to be protected against oxidative stress consistent with their progenitor cell character, and combined inhibition of these antioxidants increased ROS levels in EPCs and impaired EPC survival and migration.
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Double-Edged Role of Statins in Angiogenesis Signaling
TL;DR: The data suggest that statins exert a double-edged role in angiogenesis signaling by promoting the migration of mature endothelial cells and endothelial progenitor cells at low concentrations, whereas the antiangiogenic effects were achieved only at high concentrations.