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Wolf K. Hofmann
Researcher at Charité
Publications - 30
Citations - 6126
Wolf K. Hofmann is an academic researcher from Charité. The author has contributed to research in topics: Leukemia & Myeloid leukemia. The author has an hindex of 19, co-authored 30 publications receiving 5780 citations. Previous affiliations of Wolf K. Hofmann include Humboldt University of Berlin & University of California, Los Angeles.
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Journal ArticleDOI
Long-Term Control of HIV by CCR5 Delta32/Delta32 Stem-Cell Transplantation
Gero Hütter,Daniel Nowak,Maximilian Mossner,Susanne Ganepola,Kristina Allers,Thomas Schneider,Jörg Hofmann,Claudia Kücherer,Olga Blau,Igor Wolfgang Blau,Wolf K. Hofmann,Eckhard Thiel +11 more
TL;DR: Stem cells from a donor who was homozygous for CCR5 delta32 were transplanted in a patient with acute myeloid leukemia and HIV-1 infection and the patient remained without viral rebound 20 months after transplantation and discontinuation of antiretroviral therapy.
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Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells
Carmen Urbich,Alexandra Aicher,Christopher Heeschen,Elisabeth Dernbach,Wolf K. Hofmann,Andreas M. Zeiher,Stefanie Dimmeler +6 more
TL;DR: EPC exhibit a high expression of angiogenic growth factors, which enhanced migration of mature endothelial cells and tissue resident cardiac progenitor cells, and the enhanced expression of cytokines may be a supportive mechanism to improve blood vessel formation and cardiac regeneration after cell therapy.
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Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease
Stefan Stein,Marion Ott,Stephan Schultze-Strasser,Anna Jauch,Barbara Burwinkel,Barbara Burwinkel,Andrea Kinner,Manfred Schmidt,Alwin Krämer,Joachim Schwäble,Hanno Glimm,Ulrike Koehl,Carolin Preiss,Claudia R. Ball,Hans Martin,Gudrun Göhring,Kerstin Schwarzwaelder,Wolf K. Hofmann,Kadin Karakaya,Sandrine Tchatchou,Sandrine Tchatchou,Rongxi Yang,Rongxi Yang,Petra Reinecke,Klaus Kühlcke,Brigitte Schlegelberger,Adrian J. Thrasher,Dieter Hoelzer,Reinhard Seger,Christof von Kalle,Manuel Grez +30 more
TL;DR: It is shown that forced overexpression of EVI1 in human cells disrupts normal centrosome duplication, linking EVI 1 activation to the development of genomic instability, monosomy 7 and clonal progression toward myelodysplasia.
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Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization
Michael Potente,Carmen Urbich,Ken-ichiro Sasaki,Wolf K. Hofmann,Christopher Heeschen,Alexandra Aicher,Ramya Kollipara,Ronald A. DePinho,Andreas M. Zeiher,Stefanie Dimmeler +9 more
TL;DR: It is shown that Foxo1 and Foxo3a are the most abundant Foxo isoforms in mature endothelial cells and that overexpression of constitutively active Foxo 1 or Foxo 3a, but not Foxo4, significantly inhibits endothelial cell migration and tube formation in vitro.
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HMG-CoA Reductase Inhibitors Reduce Senescence and Increase Proliferation of Endothelial Progenitor Cells via Regulation of Cell Cycle Regulatory Genes
Birgit Assmus,Carmen Urbich,Alexandra Aicher,Wolf K. Hofmann,Judith Haendeler,Lothar Rössig,Ioakim Spyridopoulos,Andreas M. Zeiher,Stefanie Dimmeler +8 more
TL;DR: Atorvastatin-mediated prevention of EPC senescence appears to be mediated by the regulation of various cell cycle proteins, and induction ofEPC proliferation by statins in vitro may importantly improve the functional activity of E PCs for potential cell therapy.