Elisabeth M. Busch-Nentwich

TL;DR: An active project that aims to identify and phenotype the disruptive mutations in every zebra fish protein-coding gene, using a well-annotated zebrafish reference genome sequence, high-throughput sequencing and efficient chemical mutagenesis.

TL;DR: The screening of embryonic lethal and sub-viable mouse knockout lines from the Deciphering the Mechanisms of Developmental Disorders program for placental phenotypes found that 68% of knockout lines that are lethal at or after mid-gestation exhibited placental dysmorphologies, which highlight the hugely under-appreciated importance of placental defects in contributing to abnormal embryo development and suggest key molecular nodes that govern placenta formation.

TL;DR: An mRNA expression time course of zebrafish development across 18 time points from 1 cell to 5 days post-fertilisation sampling individual and pools of embryos shows a class of over 100 previously uncharacterised zinc finger domain containing genes, located on the long arm of chromosome 4, is expressed in a sharp peak during zygotic genome activation.

TL;DR: This work demonstrates that Fgf and Notch signaling inhibit proliferation of support cells in parallel by inhibiting Wnt signaling, which is crucial for identifying factors to trigger hair cell production in mammals.

TL;DR: In this paper, the authors analyzed mRNA processing in seven zebrafish lines with mutations expected to disrupt gene function, generated by CRISPR/Cas9 or ENU mutagenesis methods.