E
Elizabeth J. Robertson
Researcher at University of Oxford
Publications - 79
Citations - 8407
Elizabeth J. Robertson is an academic researcher from University of Oxford. The author has contributed to research in topics: Endoderm & Cellular differentiation. The author has an hindex of 43, co-authored 79 publications receiving 7488 citations. Previous affiliations of Elizabeth J. Robertson include Wellcome Trust Centre for Human Genetics.
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Journal ArticleDOI
Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo
TL;DR: Relevant studies in lower vertebrates indicate the conservation and divergence of regulatory mechanisms for cell lineage allocation and axis patterning in the early mammalian embryo.
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Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection.
Michael A. Paley,Daniela C. Kroy,Pamela M. Odorizzi,Jonathan B. Johnnidis,Douglas V. Dolfi,Burton E. Barnett,Elizabeth K. Bikoff,Elizabeth J. Robertson,Georg M. Lauer,Steven L. Reiner,E. John Wherry +10 more
TL;DR: It is demonstrated that the T-box transcription factors T-bet and Eomesodermin differentially regulate two phenotypically and functionally distinct subsets of antiviral CD8+ T cells in mice, which may be important for antiviral immunity during chronic viral infections in humans.
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An Nkx2-5/Bmp2/Smad1 Negative Feedback Loop Controls Heart Progenitor Specification and Proliferation
Owen W.J. Prall,Mary K. Menon,Mark J. Solloway,Yusuke Watanabe,Stéphane Zaffran,Fanny Bajolle,Christine Biben,Jim J. McBride,Bronwyn R. Robertson,Hervé Chaulet,Fiona A. Stennard,Natalie Wise,Daniel Schaft,Orit Wolstein,Milena B. Furtado,Hidetaka Shiratori,Kenneth R. Chien,Hiroshi Hamada,Brian L. Black,Yumiko Saga,Elizabeth J. Robertson,Margaret Buckingham,Richard P. Harvey,Richard P. Harvey +23 more
TL;DR: It is demonstrated that Nkx2-5 orchestrates the transition between periods of cardiac induction, progenitor proliferation, and OFT morphogenesis via a Smad1-dependent negative feedback loop, which may be a frequent molecular target in CHD.
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Cell fate decisions within the mouse organizer are governed by graded Nodal signals
TL;DR: It is conclusively demonstrated that graded Nodal/Smad2 signals govern allocation of the axial mesendoderm precursors that selectively give rise to the ADE and PCP mesoderm.
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Pluripotency factors regulate definitive endoderm specification through eomesodermin
Adrian Kee Keong Teo,Sebastian J. Arnold,Matthew Trotter,Stephanie Brown,Lay Teng Ang,Zhenzhi Chng,Elizabeth J. Robertson,N. Ray Dunn,Ludovic Vallier +8 more
TL;DR: Together, these results provide for the first time a comprehensive molecular model connecting the transition from pluripotency to endoderm specification during mammalian development.