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Elizabeth A. Pehek
Researcher at Case Western Reserve University
Publications - 27
Citations - 2888
Elizabeth A. Pehek is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Dopamine & Dopaminergic. The author has an hindex of 22, co-authored 27 publications receiving 2745 citations. Previous affiliations of Elizabeth A. Pehek include Northeast Ohio Medical University & United States Department of Veterans Affairs.
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Journal ArticleDOI
Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission
TL;DR: The anatomical evidence for the presence of each 5-HT receptor subtype in dopaminergic regions of the brain and the neuropharmacological evidence demonstrating regulation of each DA pathway are summarized.
Journal ArticleDOI
Pet-1 ETS Gene Plays a Critical Role in 5-HT Neuron Development and Is Required for Normal Anxiety-like and Aggressive Behavior
Timothy John Hendricks,Dmitry V. Fyodorov,Lauren J. Wegman,Nadia B. Lelutiu,Elizabeth A. Pehek,Bryan K. Yamamoto,Jerry Silver,Edwin J. Weeber,J. David Sweatt,Evan S. Deneris +9 more
TL;DR: It is shown that in mice lacking Pet-1, the majority of 5-HT neurons fail to differentiate and remaining ones show deficient expression of genes required for5-HT synthesis, uptake, and storage.
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Evidence for the preferential involvement of 5-HT2A serotonin receptors in stress- and drug-induced dopamine release in the rat medial prefrontal cortex.
Elizabeth A. Pehek,Elizabeth A. Pehek,Christine Nocjar,Christine Nocjar,Bryan L. Roth,Tara A Byrd,Omar S. Mabrouk,Omar S. Mabrouk +7 more
TL;DR: Results indicate that stimulation of cortical 5-HT2A receptors increases the release of dopamine from the mesocortical system, and suggest that this effect may be mediated by increases in glutamate release from corticotegmental projections to the VTA.
Journal ArticleDOI
Modulation of dopamine release by striatal 5-HT2C receptors.
Katherine D. Alex,Gregory J. Yavanian,Hewlet G. McFarlane,Charles P. Pluto,Elizabeth A. Pehek,Elizabeth A. Pehek +5 more
TL;DR: The results suggest that the nigrostriatal system is regulated by 5‐HT2C receptors localized in the dorsal striatum, and that serotonin (5‐HT) modulates striatal and prefrontocortical DA concentrations may lead to improvements in the treatment of diverse syndromes.
Journal ArticleDOI
Localization of 5-HT2A receptors on dopamine cells in subnuclei of the midbrain A10 cell group
TL;DR: An anatomical basis is provided for the physiological modulation of dopamine neurons in the rostral ventral tegmental area either directly, by 5-HT(2A) receptors localized on dopamine cells, or indirectly, through a non-dopaminergic mechanism.