E
Elizabeth Garabedian
Researcher at National Institutes of Health
Publications - 51
Citations - 2405
Elizabeth Garabedian is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Genetic enhancement & Immunodeficiency. The author has an hindex of 18, co-authored 42 publications receiving 1886 citations. Previous affiliations of Elizabeth Garabedian include Cincinnati Children's Hospital Medical Center & RMIT University.
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Journal ArticleDOI
Actionable Diagnosis of Neuroleptospirosis by Next-Generation Sequencing
Michael R. Wilson,Samia N. Naccache,Erik Samayoa,Mark Biagtan,Hiba Bashir,Guixia Yu,Shahriar M. Salamat,Sneha Somasekar,Scot Federman,Steve Miller,Robert A. Sokolic,Elizabeth Garabedian,Fabio Candotti,Rebecca H. Buckley,Kurt D. Reed,Teresa L. Meyer,Christine M. Seroogy,Renee Galloway,Sheryl L Henderson,James E. Gern,Joseph L. DeRisi,Charles Y. Chiu +21 more
TL;DR: A 14-year-old boy with severe combined immunodeficiency presented three times to a medical facility over a period of 4 months with fever and headache that progressed to hydrocephalus and status epilepticus necessitating a medically induced coma, confirming evidence of Leptospira santarosai infection.
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Gene therapy for adenosine deaminase–deficient severe combined immune deficiency: clinical comparison of retroviral vectors and treatment plans
Fabio Candotti,Kit L. Shaw,Linda M. Muul,Denise Carbonaro,Robert A. Sokolic,Christopher S. Choi,Shepherd H. Schurman,Elizabeth Garabedian,Chimene Kesserwan,G. Jayashree Jagadeesh,Pei Yu Fu,Eric H. Gschweng,Aaron R. Cooper,John F. Tisdale,Kenneth I. Weinberg,Neena Kapoor,Ami J. Shah,Hisham Abdel-Azim,Xiao Jin Yu,Monika Smogorzewska,Alan S. Wayne,Howard M. Rosenblatt,Carla M. Davis,Celine G. Hanson,Radha G. Rishi,Xiaoyan Wang,David W. Gjertson,Otto O. Yang,Arumugam Balamurugan,Gerhard Bauer,Joanna A. Ireland,Barbara C. Engel,Gregory M. Podsakoff,Michael S. Hershfield,R. Michael Blaese,Robertson Parkman,Donald B. Kohn +36 more
TL;DR: The studies directly demonstrate the importance of providing nonmyeloablative pretransplantation conditioning to achieve therapeutic benefits with gene therapy for ADA-deficient severe combined immunodeficiency.
Journal ArticleDOI
Persistence and expression of the adenosine deaminase gene for 12 years and immune reaction to gene transfer components: long-term results of the first clinical gene therapy trial.
Linda M. Muul,Laura M. Tuschong,Sherry L. Soenen,G. Jayashree Jagadeesh,W. Jay Ramsey,Zhifeng Long,Charles S. Carter,Elizabeth Garabedian,Melinna Alleyne,Margaret R. Brown,Wendy Bernstein,Shepherd H. Schurman,Thomas A. Fleisher,Susan F. Leitman,Cynthia E. Dunbar,R. Michael Blaese,Fabio Candotti +16 more
TL;DR: Data collected from these original patients have provided novel information about the longevity of T lymphocytes in humans and persistence of gene expression in vivo from vectors driven by the Moloney murine leukemia virus long-terminal repeat (LTR) promoter.
Journal ArticleDOI
Somatic mosaicism in Wiskott–Aldrich syndrome suggests in vivo reversion by a DNA slippage mechanism
Taizo Wada,Shepherd H. Schurman,Makoto Otsu,Elizabeth Garabedian,Hans D. Ochs,David L. Nelson,Fabio Candotti +6 more
TL;DR: Findings strongly suggest that DNA polymerase slippage was the cause of the original germ-line insertion mutation in this family and that the same mechanism was responsible for its deletion in one of the propositus T cell progenitors, thus leading to reversion mosaicism.
Journal ArticleDOI
Cancer in primary immunodeficiency diseases: Cancer incidence in the United States Immune Deficiency Network Registry
P.C. Mayor,Kevin H. Eng,Kelly L. Singel,Scott I. Abrams,Kunle Odunsi,Kirsten B. Moysich,Ramsay Fuleihan,Elizabeth Garabedian,Patricia L. Lugar,Hans D. Ochs,Francisco A. Bonilla,Rebecca H. Buckley,Kathleen E. Sullivan,Zuhair K. Ballas,Charlotte Cunningham-Rundles,Brahm H. Segal,Brahm H. Segal +16 more
TL;DR: Data point to a restricted role of the immune system in protecting from specific cancers, as an excess of lymphoma in specific PIDD populations principally drove this increased incidence, while no increased risk of the most common solid tumor malignancies was observed.