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Xiaoyan Wang
Researcher at University of California, Los Angeles
Publications - 106
Citations - 5632
Xiaoyan Wang is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Genetic enhancement & Progenitor cell. The author has an hindex of 29, co-authored 95 publications receiving 4039 citations. Previous affiliations of Xiaoyan Wang include University of California.
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Journal ArticleDOI
Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression.
Angel Garcia-Diaz,Daniel Sanghoon Shin,Blanca Homet Moreno,Justin Saco,Helena Escuin-Ordinas,Gabriel Abril Rodriguez,Jesse M. Zaretsky,Lu Sun,Willy Hugo,Xiaoyan Wang,Giulia Parisi,Cristina Puig Saus,Davis Y. Torrejon,Thomas G. Graeber,Begonya Comin-Anduix,Siwen Hu-Lieskovan,Robert Damoiseaux,Roger S. Lo,Antoni Ribas +18 more
TL;DR: Analysis of biopsy specimens from patients with melanoma confirmed interferon signature enrichment and upregulation of gene targets for STAT1/STAT2/STAT3 and IRF1 in anti-PD-1-responding tumors.
Journal ArticleDOI
Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress.
Jennifer Tsoi,Lidia Robert,Kim H. T. Paraiso,Carlos Galvan,Katherine M. Sheu,Johnson Lay,Deborah J.L. Wong,Mohammad Atefi,Roksana Shirazi,Xiaoyan Wang,Daniel Braas,Catherine S. Grasso,Nicolaos Palaskas,Antoni Ribas,Thomas G. Graeber +14 more
TL;DR: In this paper, gene expression analysis of human melanoma cell lines and patient tumors revealed that melanoma follows a two-dimensional differentiation trajectory that can be subclassified into four progressive subtypes associated with subtype-specific sensitivity to iron-dependent oxidative stress and cell death known as ferroptosis.
Journal ArticleDOI
CTLA4 blockade broadens the peripheral T cell receptor repertoire
Lidia Robert,Jennifer Tsoi,Xiaoyan Wang,Ryan O. Emerson,Blanca Homet,Blanca Homet,Thinle Chodon,Stephen Mok,Rong R. Huang,Alistair J. Cochran,Begonya Comin-Anduix,Richard C. Koya,Thomas G. Graeber,Harlan Robins,Antoni Ribas +14 more
TL;DR: There was a significant difference in the total unique productive TCR V-beta CDR3 sequences between patients experiencing toxicity with tremelimumab compared with patients without toxicity, representing a pharmacodynamic effect of how this class of antibodies modulates the human immune system.
Journal ArticleDOI
PD-1 Blockade Expands Intratumoral Memory T Cells
Antoni Ribas,Daniel Sanghoon Shin,Jesse M. Zaretsky,Juliet Wairimu Frederiksen,Andrew E. Cornish,Earl Avramis,Elizabeth Seja,Christine Kivork,Janet C. Siebert,Paula Kaplan-Lefko,Xiaoyan Wang,Bartosz Chmielowski,John A. Glaspy,Paul C. Tumeh,Thinle Chodon,Dana Pe'er,Begoña Comin-Anduix +16 more
TL;DR: PD-1 blockade increases the frequency of T cells, B cells, and myeloid-derived suppressor cells in tumors, with the CD8+ effector memory T-cell subset being the major T- cell phenotype expanded in patients with a response to therapy.
Journal ArticleDOI
Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells
Megan D. Hoban,Gregory J. Cost,Matthew C. Mendel,Zulema Romero,Michael L. Kaufman,Alok V. Joglekar,Michelle Ho,Dianne Lumaquin,David Gray,Georgia R. Lill,Aaron R. Cooper,Fabrizia Urbinati,Shantha Senadheera,Allen Zhu,Pei-Qi Liu,David Paschon,Lei Zhang,Edward J. Rebar,Andrew Wilber,Xiaoyan Wang,Philip D. Gregory,Michael C. Holmes,Andreas Reik,Roger P. Hollis,Donald B. Kohn +24 more
TL;DR: ZFN-driven gene correction in CD34(+) cells from the bone marrow of patients with SCD resulted in the production of wild-type hemoglobin tetramers, demonstrating efficient targeted cleavage at the β-globin locus with minimal off-target modification.