Elizabeth J. Read

TL;DR: Nonmyeloablative allogeneic stem-cell transplantation can induce sustained regression of metastatic renal-cell carcinoma in patients who have had no response to conventional immunotherapy, consistent with a graft-versus-tumor effect.

TL;DR: The results emphasize the importance of lineage-specific chimerism analysis to successfully manipulate engraftment after nonmyeloablative allogeneic PBSC transplantation.

TL;DR: In this article, the authors evaluated the efficiency and toxicity of labeling mammalian cells using two commercially available Food and Drug Administration (FDA)-approved agents, ferumoxides, a suspension of dextran-coated SPIO used as an MRI contrast agent, and protamine sulfate, conventionally used to reverse heparin anticoagulation but also used ex vivo as a cationic transfection agent.

TL;DR: It is suggested that IL-2 and lymphopenia are primary modulators of CD4+CD25+ Treg cell homeostasis, and Treg cells generated byIL-2 therapy expressed similar levels of FOXP3 and had similar potency for suppression compared to T Reg cells present in normal hosts.

TL;DR: This trial piloted the use of animal protein-free medium and a blood-bank-compatible closed system of gas-permeable plastic containers for culture and transduction of the PBSCs and found that these features enhance the safety of PBSCs directed gene therapy.