Journal ArticleDOI
Reactive carbonyls and oxidative stress: potential for therapeutic intervention.
TLDR
The metabolism of reactive carbonyls is described and the potential for manipulating levels of carbonyl-metabolizing enzymes through chemical intervention is discussed.About:
This article is published in Pharmacology & Therapeutics.The article was published on 2007-07-01. It has received 215 citations till now. The article focuses on the topics: Aldehyde dehydrogenase & Oxidative stress.read more
Citations
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Inflammogenesis of Secondary Spinal Cord Injury
TL;DR: It becomes clear that SCI is a heterogeneous condition, which leads towards evidence of a restorative approach based on monotherapy with multiple targets or combinatorial treatment, and there is an urgent requirement for multi-centered, randomized trials for a large patient population.
Journal ArticleDOI
Proteomics to study adaptations in marine organisms to environmental stress.
TL;DR: Comparisons of proteomic responses of closely related congeners and populations have shown which cellular processes are critical to adapt to environmental stress, and comparative proteomics is a powerful approach to identify functionally adaptive variation.
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Activity, distribution and function of indole-3-acetic acid biosynthetic pathways in bacteria
TL;DR: The broad distribution and substrate specificity of the enzymes suggests a role for these pathways beyond plant-microbe interactions in which bacterial IAA has been best studied.
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Reactive Carbonyl Species In Vivo: Generation and Dual Biological Effects
TL;DR: Since RCS can modulate different biological processes, new tools are required to decipher the precise mechanisms underlying dual effects of RCS.
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Activation of Nrf2 signaling by natural products-can it alleviate diabetes?
TL;DR: In this paper, the authors summarize function, regulation and exogenous activation of Nrf2, as well as diabetes-linked and NRF2-susceptible forms of cellular stress.
References
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Journal ArticleDOI
Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes.
TL;DR: This review provides a comprehensive summary on the chemical properties of 4-hydroxyalkenals and malonaldehyde, the mechanisms of their formation and their occurrence in biological systems and methods for their determination, as well as the many types of biological activities described so far.
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Global Burden of Diabetes, 1995–2025: Prevalence, numerical estimates, and projections
TL;DR: This report supports earlier predictions of the epidemic nature of diabetes in the world during the first quarter of the 21st century and provides a provisional picture of the characteristics of the diabetes epidemic.
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Oxidative stress: oxidants and antioxidants
TL;DR: These low molecular mass antioxidant molecules add significantly to the defense provided by the enzymes superoxide dismutase, catalase and glutathione peroxidases, which are termed ‘oxidative stress’.
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The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance.
John D. Hayes,David J. Pulford +1 more
TL;DR: The biochemical functions of GST are described to show how individual isoenzymes contribute to resistance to carcinogens, antitumor drugs, environmental pollutants, and products of oxidative stress, and to allow identification of factors that may modulate resistance to specific noxious chemicals.
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Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway
TL;DR: The development of Nrf2 knockout mice has provided key insights into the toxicological importance of this pathway, and this review highlights the key elements in this adaptive response to protection against acute and chronic cell injury provoked by environmental stresses.