Elke Nolte

TL;DR: The results indicate that combinations of miRNAs are promising biomarkers for the diagnosis of prostate cancer and extend the knowledge about the deregulation of mi RNAs in prostate cancer.

TL;DR: In primary samples of CaP, a direct correlation between reduction of SEC23A mRNA and overexpression of miR-375 but not ofMiRNAs is found, and it is shown that both miRNAs downregulate Sec23A protein expression when ectopically expressed in human 293T cells.

TL;DR: Deep sequencing of miRNA expression profiles of prostate carcinoma by deep sequencing, with increasing tumor stage relative to corresponding nonmalignant and healthy prostate tissue, and detected clearly changed mi RNA expression patterns reveals relevant miRNAs in prostate cancer that may have biomarker and therapeutic potential.

TL;DR: ZNF217 could be identified as an oncogene that is overexpressed in PCa and affects the growth of PCa cell lines, whereas the function of IPO7 remains to be elucidated in greater detail.

TL;DR: It is shown that certain microRNAs are extensively deregulated in prostate cancer cell lines and primary clinical cancer samples and that down‐regulation of miR‐145 may contribute to the increased expression of most ERG splice variants sharing the miR •145 target sequence in their 3′ untranslated region.