Martin Hart

TL;DR: The experimentally validated miRNAs will contribute to revising targetomes hypothesized by utilizing falsely annotated miRNA candidates, 1115 of which are currently annotated in miRBase V22.

TL;DR: While there is apparently no ideal platform for all challenges of miRNome analyses, cPAS shows high technical reproducibility and supplements the hitherto available platforms.

TL;DR: In this article, a web-based solution called miRTargetLink is developed for automatic analysis of miRNA targeting genes, where validated and predicted targets are extracted from databases and an interaction network is presented, and users can select whether predicted targets, experimentally validated targets with strong or weak evidence, or combinations of those are considered.

TL;DR: Deep sequencing of miRNA expression profiles of prostate carcinoma by deep sequencing, with increasing tumor stage relative to corresponding nonmalignant and healthy prostate tissue, and detected clearly changed mi RNA expression patterns reveals relevant miRNAs in prostate cancer that may have biomarker and therapeutic potential.

TL;DR: ZNF217 could be identified as an oncogene that is overexpressed in PCa and affects the growth of PCa cell lines, whereas the function of IPO7 remains to be elucidated in greater detail.