Ellen J. O'Flaherty

TL;DR: The relationship among dose, metabolism and hepatotoxicity in mice which resulted from subchronic exposure to the chlorinated solvents trichloroethylene and perchloroethylenes were examined and pattern is consistent with formation of the toxic intermediate in the primary metabolic pathway of each compound.

TL;DR: The results of this study suggest that lead adversely influences bone development through disruption of mineralization during growth, consistent with effects observed in the metaphyseal regions of bone in lead-exposed rats and pigs.

TL;DR: An expert panel was convened to evaluate the U.S. Environmental Protection Agency's proposed guidelines for Carcinogen Risk Assessment through their application to data sets for chloroform (CHCl3) and dichloroacetic acid (DCA), and was very enthusiastic about the evolution of these proposed guidelines.

TL;DR: In this article, a framework is presented within which to organize consideration of appropriate measures of delivered dose and selection of an appropriate procedure for interspecies conversion of kinetically equivalent doses, and the effects of conventional scaling procedures on initial and steady-state concentrations and on areas under the blood concentration curve are shown.