Elmar Krieger

TL;DR: It is shown that DJ-1 mutations are associated with PARK7, a monogenic form of human parkinsonism, and these findings indicate that loss ofDJ-1 function leads to neurodegeneration.

TL;DR: An all‐atom force field aimed at protein and nucleotide optimization in vacuo (NOVA), which has been specifically designed to avoid this problem and can be applied to modeling applications as well as X‐ray and NMR structure refinement.

TL;DR: In this article, the authors describe four approaches that address the last mile of the protein folding problem and have performed well during CASP8, yielding physically realistic models: YASARA, which runs molecular dynamics simulations of models in explicit solvent, using a new partly knowledge-based all atom force field derived from Amber.

TL;DR: A new approach to solve the ‘molecular graphics problem’ is described, which shares the work between GPU and multiple CPU cores, generates high-quality results with perfectly round spheres, shadows and ambient lighting and requires only OpenGL 1.0 functionality.

TL;DR: A series of databases that run parallel to the Protein Data Bank, used for the analysis of properties of protein structures in areas ranging from structural genomics, to cancer biology and protein design, are presented.