S
Simone P. Niclou
Researcher at University of Bergen
Publications - 144
Citations - 10359
Simone P. Niclou is an academic researcher from University of Bergen. The author has contributed to research in topics: Glioma & Biology. The author has an hindex of 51, co-authored 121 publications receiving 8257 citations. Previous affiliations of Simone P. Niclou include University of Pennsylvania & University of Luxembourg.
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Journal ArticleDOI
Whole genomes redefine the mutational landscape of pancreatic cancer.
Nicola Waddell,Marina Pajic,Ann-Marie Patch,David K. Chang,Karin S. Kassahn,Peter Bailey,Amber L. Johns,David Miller,Katia Nones,Kelly Quek,Michael C.J. Quinn,Alan J. Robertson,Muhammad Zaki Hidayatullah Fadlullah,Timothy J. C. Bruxner,Angelika N. Christ,Ivon Harliwong,Senel Idrisoglu,Suzanne Manning,Craig Nourse,Ehsan Nourbakhsh,Shivangi Wani,Peter J. Wilson,Emma Markham,Nicole Cloonan,Matthew J. Anderson,J. Lynn Fink,Oliver Holmes,Stephen H. Kazakoff,Conrad Leonard,Felicity Newell,Barsha Poudel,Sarah Song,Darrin Taylor,Nick Waddell,Scott Wood,Qinying Xu,Jianmin Wu,Mark Pinese,Mark J. Cowley,Hong C. Lee,Marc D. Jones,Adnan Nagrial,Jeremy L. Humphris,Lorraine A. Chantrill,Venessa T. Chin,Angela Steinmann,Amanda Mawson,Emily S. Humphrey,Emily K. Colvin,Angela Chou,Christopher J. Scarlett,Andreia V. Pinho,Marc Giry-Laterriere,Ilse Rooman,Jaswinder S. Samra,James G. Kench,Jessica A. Pettitt,Neil D. Merrett,Christopher W. Toon,Krishna Epari,Nam Q. Nguyen,Andrew Barbour,Nikolajs Zeps,Nigel B. Jamieson,Janet Graham,Simone P. Niclou,Rolf Bjerkvig,Robert Grützmann,Daniela Aust,Ralph H. Hruban,Anirban Maitra,Christine A. Iacobuzio-Donahue,Christopher L. Wolfgang,Richard A. Morgan,Rita T. Lawlor,Vincenzo Corbo,Claudio Bassi,Massimo Falconi,Giuseppe Zamboni,Giampaolo Tortora,Margaret A. Tempero,Anthony J. Gill,James R. Eshleman,Christian Pilarsky,Aldo Scarpa,Elizabeth A. Musgrove,John V. Pearson,Andrew V. Biankin,Sean M. Grimmond +88 more
TL;DR: Genomic instability co-segregated with inactivation of DNA maintenance genes (BRCA1, BRCA2 or PALB2) and a mutational signature of DNA damage repair deficiency, and 4 of 5 individuals with these measures of defective DNA maintenance responded to platinum therapy.
Journal ArticleDOI
Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma
Olivier Keunen,Mikael Johansson,Anais Oudin,Morgane Sanzey,Siti Aminah Abdul Rahim,Fred Fack,Frits Thorsen,Torfinn Taxt,Michal Bartoš,Radovan Jirik,Hrvoje Miletic,Jian Wang,Daniel Stieber,Linda Elin Birkhaug Stuhr,Ingrid Moen,Cecilie Brekke Rygh,Rolf Bjerkvig,Simone P. Niclou +17 more
TL;DR: The present work underlines the need to combine anti-angiogenic treatment in GBMs with drugs targeting specific signaling or metabolic pathways linked to the glycolytic phenotype, and suggests that vascular remodeling induced by anti-VEGF treatment leads to a more hypoxic tumor microenvironment.
Journal ArticleDOI
Glutamine Synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma
Saverio Tardito,Anais Oudin,Shafiq U. Ahmed,Fred Fack,Olivier Keunen,Liang Zheng,Hrvoje Miletic,Per Øystein Sakariassen,Adam Weinstock,Allon Wagner,Susan L. Lindsay,Andreas K. Hock,Susan C. Barnett,Eytan Ruppin,Svein H. Mørkve,Morten Lund-Johansen,Morten Lund-Johansen,Anthony J. Chalmers,Rolf Bjerkvig,Simone P. Niclou,Eyal Gottlieb +20 more
TL;DR: It is shown here that in glioblastoma (GBM) cells, almost half of the Gln-derived glutamate (Glu) is secreted and does not enter the TCA cycle, and that inhibiting glutaminolysis does not affect cell proliferation.
Journal ArticleDOI
Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment.
Anna Dirkse,Anna Golebiewska,Thomas Buder,Thomas Buder,Petr V. Nazarov,Arnaud Muller,Suresh Poovathingal,Nicolaas H. C. Brons,Sonia Leite,Nicolas Sauvageot,Dzjemma Sarkisjan,Mathieu Seyfrid,Sabrina Fritah,Daniel Stieber,Alesandro Michelucci,Frank Hertel,Christel Herold-Mende,Francisco Azuaje,Alexander Skupin,Rolf Bjerkvig,Andreas Deutsch,Anja Voss-Böhme,Anja Voss-Böhme,Simone P. Niclou +23 more
TL;DR: It is reported that cells expressing CSC-associated cell membrane markers in Glioblastoma do not represent a clonal entity defined by distinct functional properties and transcriptomic profiles, but rather a plastic state that most cancer cells can adopt.
Journal ArticleDOI
Critical Appraisal of the Side Population Assay in Stem Cell and Cancer Stem Cell Research
TL;DR: The value of multicolor phenotyping, the impact of DNA ploidy, and the importance of distinguishing graft versus host cells for an appropriate SP discrimination are highlighted.